Results 51 to 60 of about 9,959,275 (238)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Health equity in urban and rural settings: implementation of the place standard tool in Spain

open access: yesFrontiers in Public Health
The physical, social, and economic characteristics of neighborhoods and municipalities determine the health of their residents, shaping their behaviors and choices regarding health and well-being.
Ana Ocaña-Ortiz   +18 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Operation of the Selected Local Action Group

open access: yesActa Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2015
The main objective of this article is to compare the current operation of elected local action group with the concept of learning regions. This comparison is built on detailed knowledge and understanding of the operation of local action group Podbrnensko
Lukáš Nevěděl, Miroslav Horák
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Local resilience agents [PDF]

open access: yes
Through the Village Education Resource Center, Practical Action has been working in Bangladesh to supplement the capacity of local governments to reduce the risks of flooding through training local resilience agents on flood preparedness, livelihood ...
Action, Practical
core  

Breaking down barriers in building teacher competence [PDF]

open access: yes, 2012
Teachers may well be made, not born, and appointments to academic positions are often made without regard to the appointee’s prior experience or competence in teaching.
Bruce Ferguson, Pip   +1 more
core  

The microbiome in human skin aging

open access: yesFEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana   +3 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

The role of digital participation platforms in risk-informed development: A case study of Surabaya, Indonesia

open access: yesProgress in Disaster Science
There is growing policy consensus around the need for development to be risk-informed. In parallel, digital technologies are increasingly deployed to enhance participation within a wide range of policy domains, particularly in urban settings.
Ronan McDermott   +6 more
doaj   +1 more source

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