Results 111 to 120 of about 3,917,568 (316)

Development and Antitumor Evaluation of Doxorubicin-Loaded Two-Layered Sheets for Local Chemotherapy via Direct Drug Application to the Tumor Surface

Pharmaceutics
Background/Objectives: Non-specific distribution of anticancer drugs to non-lesional areas of the body and organs, followed by their rapid disappearance, limits the drug concentration in the tumor, impacting the chemotherapy efficacy.
Nao Mitsudome, Mayuko Matsumoto, Yui Murakami, Fei Yuan, Hirotaka Miyamoto, Shintaro Fumoto, Akira Toriba, Koyo Nishida   +7 more
doaj   +1 more source

Effect of local administration of injectable platelet-rich fibrin on root resorption during orthodontic tooth movement in dogs. [PDF]

Dent Res J (Isfahan), 2023
Sedaghati G, Feizbakhsh M, Esnaashari N, Razavi SM.   +3 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

DECENTRALIZATION AND LOCAL AUTONOMY - LOCAL PUBLIC MANAGEMENT DEFINING PRINCIPLES [PDF]

In the context of multiplication and diversification of the requirements andsocial needs, public administration, together with its authorities needs to operate throughits entire activity to meet and resolve, under the best conditions, the public ...
Irina Bilouseac, Petronela Zaharia
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Effects of early local administration of high-dose bFGF on a recurrent laryngeal nerve injury model. [PDF]

J Otolaryngol Head Neck Surg, 2023
Goto T, Ueha R, Sato T, Yamasoba T.
europepmc   +1 more source

INTEGRATED GOVERNANCE – A REAL STRATEGIC OPTION FOR AN EFFECTIVE ROMANIAN LOCAL PUBLIC ADMINISTRATION [PDF]

Based on the fact that governance is referring to the processes of governing which includes all public management organizations, the paper contains some opinions of the specialists concerning governance and integrated governance concept.
Armenia ANDRONICEANU
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Local administration of mesenchymal stromal cells is safe and modulates the immune compartment in ulcerative proctitis. [PDF]

JCI Insight, 2023
Ouboter LF, Barnhoorn MC, Verspaget HW, Plug L, Pool ES, Szuhai K, Hawinkels LJ, van Pel M, Zwaginga JJ, Roelen D, Koning F, Pascutti MF, van der Meulen-de Jong AE.   +12 more
europepmc   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source