Results 71 to 80 of about 3,917,568 (316)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

STRATEGIC MANAGEMENT – MODEL AND TOOL FOR THE DEVELOPMENT OF THE LOCAL COMMUNITIES MANAGEMENT, IN THE STATE REFORM CONTEXT [PDF]

Ever since 2007, along with the completion of the EU accession process, but also before that, our country has constantly focused on improving local government standards either through a solid and sustained reform or through public system management ...
Ana Claudia TAPARDEL
core  

Agile and Pro-Active Public Administration as a Collaborative Networked Organization

, 2010
In highly competitive, globalized economies and societies of always-on-line people intensively using the Internet and mobile phones, public administrations have to adapt to new challenges.
Cellary, Wojciech, Picard, Willy
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Local Vancomycin Application Reduces Periprosthetic Joint Infections in Oncologic Megaprosthetic Reconstruction: A Retrospective Cohort Study

Antibiotics
Background/Objectives: Periprosthetic joint infections (PJIs) represent a serious complication following musculoskeletal tumor resection and megaprosthetic reconstruction.
Andreas G. Tsantes, Dimitrios V. Papadopoulos, Stavros Goumenos, Petros Ioannou, Nikolaos Stavropoulos, Eleni Petrou, Ioannis G. Trikoupis, Christos Koutserimpas, Alexandra Mpakosi, Vasileios A. Kontogeorgakos, Stefanos Bonovas, Panayiotis J. Papagelopoulos, Athanasios Tsakris, Argirios E. Tsantes   +13 more
doaj   +1 more source

Politics, Relief, and Reform: The Transformation of America's Social Welfare System during the New Deal [PDF]

The American social welfare system was transformed during the 1930s. Prior to the New Deal public relief was administered almost exclusively by local governments. The administration of local public relief was widely thought to be corrupt.
John Joseph Wallis, Price Fishback, Shawn Kantor   +2 more
core  

Police Executive Research Forum: Freeing Local Police from Immigration Enforcement [PDF]

, 2011
Dealing with immigration issues is one of the most critical and frustrating challenges police and sheriffs' departments currently face. To solve this problem and take some pressure off their members, the Police Executive Research Forum (PERF) has ...
Karen Theroux
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

SUBSTANCE OF FISCAL DECENTRALIZATION IN THE REPUBLIC OF SERBIA

Pravo, 2008
Pursuant to the Local Self-Government Act adopted in February 2002, the fiscal decentralization has been carried out without the institutional decentralization of functions of the central tax administration, whereby only the affirmation of the self ...
Vesna Aleksić
doaj