Results 91 to 100 of about 5,960,966 (303)

DECENTRALIZATION OF POWER UNDER CONDITIONS OF WAR: CHALLENGES FOR DEMOCRATIC LOCAL SELF-GOVERNMENT ON THE EXAMPLE OF KHARKIV REGION

Вісник Харківського національного університету імені В. Н. Каразіна: Серія "Питання політології"
The article analyzes impact of a full-scale war on the implementation of the decentralization reform. The decentralization reform, which began in 2014, was initially implemented against the backdrop of the Russian-Ukrainian war, but during 2022-2024 the ...
Anton Avksentiev
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

The Effectiveness of Social Software for Public Engagement

International Journal of Engineering Business Management, 2012
This article examines the level of diffusion of social software (SS) in Italian local administrations and the effectiveness of these technologies in supporting public engagement, focusing on the specific case of Facebook in Italian municipalities. Public
Deborah Agostino
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Big Local Partnership Reviews, 2015-2023

copyright UK Data Service and data collection copyright owner.Big Local is a long-term, place-based funding programme in England aimed at empowering residents in selected communities to lead local change, build community capacity, and improve outcomes ...
Local Trust
core   +1 more source

ON THE ISSUE OF INTERACTION BETWEEN STATE EXECUTIVE AUTHORITIES AND LOCAL SELF-GOVERNMENT BODIES IN UKRAINE AND THE EU COUNTRIES

Baltic Journal of Economic Studies
The purpose of the article is to study the mechanism and problems of interaction between public executive authorities and local self-government bodies in Ukraine and to determine the specifics of its implementation in the EU countries with a view to ...
Oleksiy Kavylin
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Big Local Partnership Member Surveys, 2016-2024

copyright UK Data Service and data collection copyright owner.Big Local is a long-term, place-based funding programme in England aimed at empowering residents in selected communities to lead local change, build community capacity, and improve outcomes ...
Local Trust
core   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source