Results 91 to 100 of about 48,373 (308)
The administrative autonomy of local authorities in Zambia under the 2016 Constitution [PDF]
, 2019 Magister Philosophiae - MPhilZambia has, since independence in 1964, endeavoured to build an effective local government system anchored on decentralisation in an effort to attain the values and principles of democracy, autonomy and transparency.
Maambo, Chilumbwa
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Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Economic competence of local government administrations: legislation improvement
, 2014 The article is dedicated to an actual problem of the present system of legislation on the local self-government development in the context of exact, detailed and legally correct systematization of the organizational and economic powers of such ...
Возна, В.О.
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Вісник Харківського національного університету імені В. Н. Каразіна: Серія "Питання політології"The article analyzes impact of a full-scale war on the implementation of the decentralization reform. The decentralization reform, which began in 2014, was initially implemented against the backdrop of the Russian-Ukrainian war, but during 2022-2024 the ...
Anton Avksentiev
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Should local public employment services be merged with local social benefit administrations?
, 2013 The German Federal government has allowed local governments of some regions (Approved Local Providers) to be solely responsible for the care of unemployment benefit II recipients. In the remaining regions Joint Local Agencies were formed, where the local
Munz, Sonja, Holzner, Christian
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
The Effectiveness of Social Software for Public Engagement
International Journal of Engineering Business Management, 2012 This article examines the level of diffusion of social software (SS) in Italian local administrations and the effectiveness of these technologies in supporting public engagement, focusing on the specific case of Facebook in Italian municipalities. Public
Deborah Agostino
doaj +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source