Results 61 to 70 of about 287,442 (317)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Strategic Planning in Turkish Local Administrations: How Participatory is it?

Current Perspectives in Social Sciences
Strategic plans are more participatory, more responsive, more integrated and more empowering when compared to the traditional plans. It has been nearly 20 years since the Financial Management and Control Law in Turkey required public institutions ...
İhsan İkizer
doaj   +1 more source

The responsibility of officials of local administrations for violations in the sphere of land relations.

Теорія і практика правознавства, 2016
Problem Setting. The article studies the question of responsibility of officials of local administrations for violations in the sphere of land relations. The analysis of scientific papers in the study area, considered issues related to the classification
А. С. Самородов
doaj   +1 more source

Dynamics of Everyday Life within Municipal Administrations in Francophone and Anglophone Africa

Africa Spectrum, 2020
Decentralisation in sub-Saharan Africa promises to build responsive institutions, hold officials to account and promote popular participation. Still, existent studies ignore the everyday interface between decentralised structures and citizens, as well as
Matthew Sabbi, Lamine Doumbia, Dieter Neubert   +2 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

The future is local? Contextualizing municipal agendas on climate change in Chile

npj Climate Action
Social science literature on the political strategies used to mitigate and adapt to climate change has discussed the possibilities of local administrations and the multifaceted obstacles in their path.
Rosa Lehmann, Alejandra Irigoyen Rios
doaj   +1 more source

Should local public employment services be merged with the local social benefit administrations? [PDF]

, 2011
The German Federal government has allowed some regions (Approved Local Providers) to be solely responsible for the care of long-term unemployed. The remaining regions had to form Joint Local Agencies, where the local social benefit administrations work ...
Holzner, Christian, Munz, Sonja
core  

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Should Local Public Employment Services be Merged with the Local Social Benefit Administrations? [PDF]

The German Federal government has allowed some regions (Approved Local Providers) to be solely responsible for the care of long-term unemployed. The remaining regions had to form Joint Local Agencies, where the local social benefit administrations work ...
Christian Holzner, Sonja Munz
core