Results 1 to 10 of about 270,955 (261)

Prolonged exposure of neonatal mice to sevoflurane leads to hyper-ramification in microglia, reduced contacts between microglia and synapses, and defects in adult behavior

Frontiers in Neurology, 2023
BackgroundProlonged exposure to general anesthetics during development is known to cause neurobehavioral abnormalities, but the cellular and molecular mechanisms involved are unclear.
Hong Li, Hong Li, Bin Zhou, Bin Zhou, Ping Liao, Daqing Liao, Linghui Yang, Jing Wang, Jin Liu, Jin Liu, Ruotian Jiang, Ruotian Jiang, Lingmin Chen, Lingmin Chen   +13 more
doaj   +1 more source

Contribution of Neuronal and Glial Two-Pore-Domain Potassium Channels in Health and Neurological Disorders

Neural Plasticity, 2021
Two-pore-domain potassium (K2P) channels are widespread in the nervous system and play a critical role in maintaining membrane potential in neurons and glia.
Yuncheng Luo, Lu Huang, Ping Liao, Ruotian Jiang   +3 more
doaj   +1 more source

Empagliflozin protects against renal ischemia/reperfusion injury in mice

Scientific Reports, 2022
Renal ischemia/reperfusion (I/R) can induce acute kidney injury. Empagliflozin is a newly developed inhibitor of sodium-glucose cotransporter-2 (SGLT2) approved as an antidiabetic medication for patients with type 2 diabetes mellitus.
Qifeng Wang, Feng Ju, Jiaxue Li, Ting Liu, Yunxia Zuo, Geoffrey W. Abbott, Zhaoyang Hu   +6 more
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General anesthesia versus local anesthesia for penetrating keratoplasty:a prospective study [PDF]

International Journal of Ophthalmology, 2014
AIM:To examine which anesthesia general or local is more effective for penetrating keratoplasty (PKP).METHODS: Patients with indications for PKP (n=141) were enrolled in a prospective study and randomly divided into general anesthesia group (group A, 70 ...
Xu Wang, Guang-Fu Dang, Ying-Mei Li, Wei-Fan Li, Xin-Yi Wu   +4 more
doaj   +1 more source

Genetic liability for diet-derived circulating antioxidants, oxidative stress, and risk of osteoarthritis: a Mendelian randomization study

Frontiers in Nutrition, 2023
BackgroundAlthough well-documented, the causal relationships between diet-derived circulating antioxidants, oxidative stress, and osteoarthritis (OA) are equivocal.
Yidan Tang, Yidan Tang, Xiaolin Xu, Xiaolin Xu, Shuangyi Zhang, Shuangyi Zhang, Weishuang Kong, Weiyi Zhang, Weiyi Zhang, Tao Zhu, Tao Zhu   +10 more
doaj   +1 more source

The volatile anesthetic isoflurane differentially inhibits voltage-gated sodium channel currents between pyramidal and parvalbumin neurons in the prefrontal cortex

Frontiers in Neural Circuits, 2023
BackgroundHow volatile anesthetics work remains poorly understood. Modulations of synaptic neurotransmission are the direct cellular mechanisms of volatile anesthetics in the central nervous system.
Jingxuan Qiu, Jingxuan Qiu, Yaoxin Yang, Yaoxin Yang, Jin Liu, Wenling Zhao, Qian Li, Qian Li, Tao Zhu, Peng Liang, Cheng Zhou   +10 more
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History of anesthesia usage in dentistry [PDF]

Stomatološki glasnik Srbije, 2005
Since prehistoric times, man has sought ways to lessen pain. With varying degrees of success he has utilized: opium, nerve compresses, cold, hypnosis, etc.
Koković Vladimir
doaj   +1 more source

Advances in the Understanding of Two-Pore Domain TASK Potassium Channels and Their Potential as Therapeutic Targets

Molecules, 2022
TWIK-related acid-sensitive K+ (TASK) channels, including TASK-1, TASK-3, and TASK-5, are important members of the two-pore domain potassium (K2P) channel family. TASK-5 is not functionally expressed in the recombinant system.
Xueming Fan, Yongzhi Lu, Guizhi Du, Jin Liu   +3 more
doaj   +1 more source

Multisite chronic pain and the risk of autoimmune diseases: A Mendelian randomization study

Frontiers in Immunology, 2023
BackgroundAccumulating evidence has demonstrated that an association between chronic pain and autoimmune diseases (AIDs). Nevertheless, it is unclear whether these associations refer to a causal relationship. We used a two-sample Mendelian randomization (
Yidan Tang, Yidan Tang, Weizhi Liu, Weizhi Liu, Weishuang Kong, Shuangyi Zhang, Shuangyi Zhang, Tao Zhu, Tao Zhu   +8 more
doaj   +1 more source

Genetically supported causality between gut microbiota, gut metabolites and low back pain: a two-sample Mendelian randomization study

Frontiers in Microbiology, 2023
BackgroundPrevious studies have implicated a vital association between gut microbiota/gut microbial metabolites and low back pain (LBP), but their causal relationship is still unclear.
Mengchan Su, Mengchan Su, Yidan Tang, Yidan Tang, Weishuang Kong, Shuangyi Zhang, Shuangyi Zhang, Tao Zhu, Tao Zhu   +8 more
doaj   +1 more source