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The thermodynamics of general and local anesthesia [PDF]
General anesthetics are known to cause depression of the freezing point of transitions in biomembranes. This is a consequence of ideal mixing of the anesthetic drugs in the membrane fluid phase and exclusion from the solid phase. Such a generic law provides physical justification of the famous Meyer-Overton rule.
Graesboll, Kaare+2 more
arxiv +7 more sources
Pain-Related Behavior and Pain Perception Associated with Intraosseous Local Anesthesia (QuickSleeper 5®) in Pediatric Patients: A Randomized Controlled Clinical Trial [PDF]
Background: Managing pain during dental procedures is crucial, particularly for children, as pain can induce anxiety. Local anesthesia is the most anxiety-inducing procedure in pediatric patients.
Zeyad A. AlRaddadi+2 more
doaj +2 more sources
Wide-awake Local Anesthesia with No Tourniquet: An Updated Review
Background: The wide-awake local anesthesia with no tourniquet (WALANT) technique has become popularized for various hand/upper extremity procedures. Before surgery, patients receive local anesthetic, consisting of lidocaine with epinephrine, and remain ...
Joey S. Kurtzman+2 more
semanticscholar +1 more source
BackgroundProlonged exposure to general anesthetics during development is known to cause neurobehavioral abnormalities, but the cellular and molecular mechanisms involved are unclear.
Hong Li+13 more
doaj +1 more source
Adverse effects following dental local anesthesia: a literature review
Local anesthesia is indispensable in dentistry. Worldwide, millions of local anesthetic injections are administered annually, and are generally considered safe invasive procedures.
J. Ho+6 more
semanticscholar +1 more source
Two-pore-domain potassium (K2P) channels are widespread in the nervous system and play a critical role in maintaining membrane potential in neurons and glia.
Yuncheng Luo+3 more
doaj +1 more source
Empagliflozin protects against renal ischemia/reperfusion injury in mice
Renal ischemia/reperfusion (I/R) can induce acute kidney injury. Empagliflozin is a newly developed inhibitor of sodium-glucose cotransporter-2 (SGLT2) approved as an antidiabetic medication for patients with type 2 diabetes mellitus.
Qifeng Wang+6 more
doaj +1 more source