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The thermodynamics of general and local anesthesia [PDF]
Biophys. J. 2014, 106: 2143-2156, 2014 General anesthetics are known to cause depression of the freezing point of transitions in biomembranes. This is a consequence of ideal mixing of the anesthetic drugs in the membrane fluid phase and exclusion from the solid phase. Such a generic law provides physical justification of the famous Meyer-Overton rule.
Graesboll, Kaare +2 more
arxiv +9 more sources
, 2018 Local anesthesia is a routine procedure in dermatological practice. This chapter deals with the basic principles of pharmacology and pharmacodynamics related to the most commonly used anesthetics in dermatology as well as its side effects, the most ...
de Abreu Camargo, Caio Lamunier
openaire +4 more sources
Wide-awake Local Anesthesia with No Tourniquet: An Updated Review
Plastic and Reconstructive Surgery, Global Open, 2021 Background: The wide-awake local anesthesia with no tourniquet (WALANT) technique has become popularized for various hand/upper extremity procedures. Before surgery, patients receive local anesthetic, consisting of lidocaine with epinephrine, and remain ...
Joey S. Kurtzman +2 more
semanticscholar +1 more source
Frontiers in Neurology, 2023 BackgroundProlonged exposure to general anesthetics during development is known to cause neurobehavioral abnormalities, but the cellular and molecular mechanisms involved are unclear.
Hong Li +13 more
doaj +1 more source
Adverse effects following dental local anesthesia: a literature review
Journal of dental anesthesia and pain medicine, 2021 Local anesthesia is indispensable in dentistry. Worldwide, millions of local anesthetic injections are administered annually, and are generally considered safe invasive procedures.
J. Ho +6 more
semanticscholar +1 more source
Neural Plasticity, 2021 Two-pore-domain potassium (K2P) channels are widespread in the nervous system and play a critical role in maintaining membrane potential in neurons and glia.
Yuncheng Luo +3 more
doaj +1 more source
Frontiers in Neural Circuits, 2023 BackgroundHow volatile anesthetics work remains poorly understood. Modulations of synaptic neurotransmission are the direct cellular mechanisms of volatile anesthetics in the central nervous system.
Jingxuan Qiu +10 more
doaj +1 more source