Results 81 to 90 of about 5,211,551 (359)

LOCAL DENTAL ANESTHESIA: PATIENTS AT RISK FOR ANAPHYLAXIS

Romanian Journal of Oral Rehabilitation, 2020
Dental procedures are usually performed under local anesthesia, with undergoing complications, like over dosage, toxicity, hypersensitivity and anaphylaxis.
Celina Silvia Stafie, Alice Mirela Murariu   +1 more
doaj  

Hemodynamic effects of local anesthetics intoxication: experimental study in swine with levobupivacaine and bupivacaine Efeitos hemodinâmicos da intoxicação com anestésicos locais: estudo experimental em suínos com levobupivacaína e bupivacaína

Acta Cirúrgica Brasileira, 2008
PURPOSE: To compare the hemodynamic repercussions following a toxic dose of levobupivacaine and bupivacaine intravascularly injected in swines. Methods: Large White pigs were anesthetized with thiopental, tracheal intubation was performed and mechanical ...
Artur Udelsmann, Sílvia Elaine Rodolfo de Sá Lorena, Samira Ubaid Girioli, William Adalberto Silva, Ana Cristina de Moraes, Nelson Adami Andreollo   +5 more
doaj   +1 more source

Local Anesthesia in Carotid Angioplasty

Journal of Endovascular Therapy, 1996
Purpose: To determine the safety and efficacy of local anesthesia for percutaneous carotid angioplasty and stenting performed via a direct common carotid access. Methods: Deep cervical plexus blockade was used for anesthesia in 22 of 32 patients (26 males; mean age 66 years) undergoing percutaneous carotid balloon angioplasty and/or stenting via direct
Christian Alessandri, Patrice Bergeron
openaire   +3 more sources

Versatile Cell Penetrating Peptide for Multimodal CRISPR Gene Editing in Primary Stem Cells

Advanced Functional Materials, EarlyView.
CRISPR machinery in diverse molecular formats (DNA, RNA, and ribonucleic protein) is complexed into nanoparticles with the cell‐friendly arginine‐alanine‐leucine‐alanine (RALA) cell‐penetrating peptide. Nanoparticles are delivered to primary mesenchymal stem cells ex vivo or locally in vivo to facilitate multimodal CRISPR gene editing. This RALA‐CRISPR
Joshua P. Graham, Jose Gabriel Castro, Lisette C. Werba, Joseph Amitrano, Luke Fardone, Kevin P. Francis, Anand Ramamurthi, Michael J. Layden, Helen O. McCarthy, Tomas Gonzalez‐Fernandez   +9 more
wiley   +1 more source

Cryo-EM structure of small-molecule agonist bound delta opioid receptor-Gi complex enables discovery of biased compound

Nature Communications
Delta opioid receptor (δOR) plays a pivotal role in modulating human sensation and emotion. It is an attractive target for drug discovery since, unlike Mu opioid receptor, it is associated with low risk of drug dependence.
Lin Cheng, Zhuang Miao, Sicen Liu, Zhe Li, Hong Fu, Chanjuan Xu, Shilong Hu, Chang Zhao, Yuxuan Liu, Tiantian Zhao, Wencheng Liu, Heli Wang, Runduo Liu, Wei Yan, Xiangdong Tang, Jianfeng Liu, Zhenhua Shao, Bowen Ke   +17 more
doaj   +1 more source

Machine Learning‐Enabled Polymer Discovery for Enhanced Pulmonary siRNA Delivery

Advanced Functional Materials, EarlyView.
This study provides an efficient approach to train a machine learning model by merging heterogeneous literature data to predict suitable polymers for siRNA delivery. Without the need for extensive laboratory synthesis, the machine learning enabled a virtual screening and successfully predicted a polymer that is validated for effective gene silencing in
Felix Sieber‐Schäfer, Min Jiang, Adrian Kromer, Anny Nguyen, Müge Molbay, Simone Pinto Carneiro, David Jürgens, Gerald Burgstaller, Bastian Popper, Benjamin Winkeljann, Olivia Monika Merkel   +10 more
wiley   +1 more source

Comparação das alterações hemodinâmicas na intoxicação aguda com bupivacaína e ropivacaína por via venosa em suínos Comparación de las alteraciones hemodinámicas en la intoxicación aguda con bupivacaina y ropivacaína por vía venosa en cerdos Comparison of hemodynamic changes in acute intoxication with intravenous bupivacaine and ropivacaine in swine

Revista Brasileira de Anestesiologia, 2009
JUSTIFICATIVA E OBJETIVOS: A ropivacaína apresentada na forma levógira pura foi introduzida para proporcionar alternativa mais segura que a bupivacaína nas anestesias locorregionais. O objetivo deste estudo foi comparar as repercussões hemodinâmicas após
Marcos De Simone Melo, William Adalberto Silva, Ana Cristina de Moraes, Artur Udelsmann   +3 more
doaj   +1 more source

Local anesthesia for transrectal ultrasound-guided biopsy of the prostate: A meta-analysis

Scientific Reports, 2017
A meta-analysis was performed to evaluate the efficacy of local anesthesia in alleviating pain during prostate biopsy. We searched relevant articles in PubMed and Embase.
Ming-chao Li, Zhengyun Wang, Hao Li, Jun Yang, K. Rao, Tao Wang, Shaogang Wang, Jihong Liu   +7 more
semanticscholar   +1 more source

Evolving Platinum‐Copper Nanostructures for Enhanced Photothermal Therapy and Controlled Copper Release in Cancer Therapy

Advanced Functional Materials, EarlyView.
Platinum‐Copper bimetallic nanoparticles may evolve depending on their synthesis under tumor microenvironment conditions and play a dual role as chemotherapeutic agents after releasing Cu ions and as near infrared photothermal agents with the Pt‐rich remaining frames.
Jose I. Garcia‐Peiro, María Sancho‐Albero, Silvia Miguel, Andrea Mosseri, Felipe Hornos, Rafael Contreras‐Montoya, Jose L. Hueso, Jesus Santamaria   +7 more
wiley   +1 more source

Spatial transcriptomics and single-nucleus RNA sequencing reveal a transcriptomic atlas of adult human spinal cord

eLife
Despite the recognized importance of the spinal cord in sensory processing, motor behaviors, and neural diseases, the underlying organization of neuronal clusters and their spatial location remain elusive.
Donghang Zhang, Yali Chen, Yiyong Wei, Hongjun Chen, Yujie Wu, Lin Wu, Jin Li, Qiyang Ren, Changhong Miao, Tao Zhu, Jin Liu, Bowen Ke, Cheng Zhou   +12 more
doaj   +1 more source