Results 31 to 40 of about 4,751,276 (340)

True Allergy to Amide Local Anesthetics: A Review and Case Presentation.

open access: yesAnesthesia Progress, 2018
Adverse reactions to local anesthetics are usually a reaction to epinephrine, vasovagal syncope, or overdose toxicity. Allergic reactions to local anesthetics are often attributed to additives such as metabisulfite or methylparaben.
Babak Bina   +4 more
semanticscholar   +1 more source

Anesthetic salts used in dentistry: a literature review

open access: yesJournal Of Oral Investigations, 2017
Local anesthetics allow a better and suitable control of pain in patients that submit to dental treatments. The pharmacology of local anesthetics is too complex, therefore it is important to know how to select the correct drug to each procedure to be ...
Guilherme Klein Parise   +2 more
doaj   +1 more source

Liposome Bupivacaine Compared to Plain Local Anesthetics to Reduce Postsurgical Pain: An Updated Meta-Analysis of Randomized Controlled Trials

open access: yesPain Research and Treatment, 2018
Objective Peripheral nerve blocks for postoperative analgesia have improved block success, but analgesia efficacy has been limited by the short duration of traditional local anesthetics.
M. Kendall   +2 more
semanticscholar   +1 more source

Mechanism of sodium channel block by local anesthetics, antiarrhythmics, and anticonvulsants

open access: yesThe Journal of General Physiology, 2017
Local anesthetics, antiarrhythmics, and anticonvulsants include both charged and electroneutral compounds that block voltage-gated sodium channels. Prior studies have revealed a common drug-binding region within the pore, but details about the binding ...
D. Tikhonov, B. Zhorov
semanticscholar   +1 more source

THE PHARMACOLOGY OF THE LOCAL ANESTHETICS [PDF]

open access: yesJournal of the American Medical Association, 1919
Acute intoxication in man from the use of the local anesthetics is far more common than is indicated by the number of recorded cases. We undertook to investigate the causes of such intoxication, and sought to find means of avoiding it, or combating it when it arises.
Robert A. Hatcher, Cary Eggleston
openaire   +2 more sources

Basophil activation test in the diagnosis of allergic reactions to local anesthetics

open access: yesМедицинский вестник Юга России, 2022
Objective: to evaluate the detection of in vitro hypersensitivity to local anesthesia drugs by fl ow cytometry.Materials and methods: in the test of activation of basophils, the determination of the hypersensitivity reaction to local anesthetics of ...
O. N. Chibisova   +2 more
doaj   +1 more source

Sweet-Tasting Ionic Conjugates of Local Anesthetics and Vasoconstrictors

open access: yesMolecules, 2021
Local anesthetics are widely utilized in dentistry, cosmetology, and medicine. Local anesthesia is essential to providing a pain-free experience during dental and local surgeries as well as cosmetic procedures.
John K. Neubert   +9 more
doaj   +1 more source

Short peptide perturbs spermatogenesis via immune microenvironment dysregulation and mitochondrial imbalance

open access: yesFEBS Open Bio, EarlyView.
In the blood–testis barrier, occludin is crucial for tight junctions. This study demonstrates that occludin‐targeting short peptides disrupt junction integrity, inducing immune cell infiltration, tumor necrosis factor‐α/interleukin‐6 secretion and mitochondrial dysfunction, ultimately triggering apoptosis.
Heng Wang, Xiaofang Tan, Deyu Chen
wiley   +1 more source

Local anesthetics for brain tumor resection: current perspectives

open access: yesLocal and Regional Anesthesia, 2018
This review summarizes the added value of local anesthetics in patients undergoing craniotomy for brain tumor resection, which is a procedure that is carried out frequently in neurosurgical practice.
J. Potters, M. Klimek
semanticscholar   +1 more source

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