Results 151 to 160 of about 6,749,458 (277)

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

201 System leadership – a leadership with special conditions. Learnings from transition to person-centred and integrated care

BMJ Open Quality
Marie Blom Niklasson, Lisbeth Löpare Johansson   +1 more
doaj   +1 more source

Public health interventions aimed at children aged 5-19 years funded by local authorities in England: a scoping review of economic analyses. [PDF]

BMC Public Health
Golder S, Dale V, Castro-Avila A, Moe-Byrne T, Afonso D, Hillcoat L, Bartlett C, Bloor K.   +7 more
europepmc   +1 more source

Authors' reply to the discussion of 'A COVID-19 Model for Local Authorities of the United Kingdom' by Mishra et al. in Session 2 of the Royal Statistical Society's Special Topic Meeting on COVID-19 transmission: 11 June 2021. [PDF]

J R Stat Soc Ser A Stat Soc, 2022
Mishra S, Scott JA, Laydon DJ, Zhu H, Ferguson NM, Bhatt S, Flaxman S, Gandy A.   +7 more
europepmc   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Health impacts of takeaway management zones around schools in six different local authorities across England: a public health modelling study using PRIMEtime. [PDF]

BMC Med
Rogers NT, Amies-Cull B, Adams J, Chang M, Cummins S, Derbyshire D, Hassan S, Keeble M, Liu B, Medina-Lara A, Savory B, Rahilly J, Smith R, Thompson C, White M, Mytton O, Burgoine T.   +16 more
europepmc   +3 more sources

189 With the goal of reducing healthcare disparities and low-value care through clinical knowledge support – the Swedish journey

BMJ Open Quality
Johanna Kain, Marie Lawrence, Mats Bojestig   +2 more
doaj   +1 more source

Trends in childhood obesity for upper tier local authorities in England between 2007/08 and 2023/24: a latent trajectory analysis. [PDF]

J Public Health (Oxf)
Rahilly J, Cortina-Borja M, Mytton O.
europepmc   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

123 With the goal of reducing healthcare disparities and low-value care through clinical knowledge support – the Swedish journey

BMJ Open Quality
Johanna Kain, Marie Lawrence, Mats Bojestig   +2 more
doaj   +1 more source