Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
'Single-handed care' initiatives and reviews of double-handed homecare packages: A survey of practices in English local authorities with adult social care responsibilities. [PDF]
Whitehead PJ +8 more
europepmc +1 more source
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
Health impacts of takeaway management zones around schools in six different local authorities across England: a public health modelling study using PRIMEtime. [PDF]
Rogers NT +16 more
europepmc +3 more sources
Increasing community vulnerability to gastrointestinal infections in austerity's shadow: a comparative study of two English local authorities. [PDF]
Rotheram S +3 more
europepmc +1 more source
Public health and climate change: How are local authorities preparing for the health impacts of our changing climate? [PDF]
Woodhall SC, Landeg O, Kovats S.
europepmc +1 more source
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley +1 more source
Dataset of project-level records for the Special Development Program for Local Authorities "Antonis Tritsis" (approvals up to August 2025), Greece. [PDF]
Makryvelios E, Papadogonas T.
europepmc +1 more source
Bayesian spatio-temporal joint disease mapping of Covid-19 cases and deaths in local authorities of England. [PDF]
Sahu SK, Böhning D.
europepmc +1 more source
Why human connection is the true metric of research success
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source

