Results 61 to 70 of about 120,588 (269)

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Nonintegrability, Chaos, and Complexity

, 2000
Two-dimensional driven dissipative flows are generally integrable via a conservation law that is singular at equilibria. Nonintegrable dynamical systems are confined to n*3 dimensions.
Arnol'd, Arnol'd, Arnol'd, Bak, Bak, Bell, Bender, Bennett, Benzi, Bowler, Burns, Constantin, Constantin, Crisanti, Cvitanovic, de Sousa Viera, Eigen, Feigenbaum, Foias, Fornenko, Fredkin, Friedrich, Garey, Gleick, Grinstein, Gunaratne, Hu, Joseph L. McCauley, Koopman, Krug, Küppers, Lindley, Lipton, Lloyd, Lofse, Lorenz, McCauley, McCauley, McCauley, McCauley, McCauley, Moore, Moore, Moore, Morowitz, Olby, Olver, Omohundro, Poincaré, Ruelle, Schuster, She, Tabor, von Neumann, von Neumann, Weinberg, Wigner, Wintner, Young   +58 more
core   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

In a land far, far away: writing (in) French Polynesia

Matraga, 2019
This article approaches, from a historical perspective, the contemporary literature of French Polynesia and the themes that are particular to it, a consequence of the complex relationship between the region and France.
Lúcia Flórido
doaj   +1 more source

Multiscale methods for problems with complex geometry

, 2016
We propose a multiscale method for elliptic problems on complex domains, e.g. domains with cracks or complicated boundary. For local singularities this paper also offers a discrete alternative to enrichment techniques such as XFEM. We construct corrected
Elfverson, Daniel, Larson, Mats G., Målqvist, Axel   +2 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Almost Global Stabilization of Curvature-Nullifiable Mechanical Systems via Pure Mechanical Feedback

Applied Sciences
Mechanical control systems structure, derived from Euler–Lagrange dynamics, is directly tied to physically meaningful coordinates such as joint angles, positions, and velocities. This work investigates when a mechanical control system can be transformed,
Marta Drążkowska, Marcin Nowicki
doaj   +1 more source

Stratified Picard-Lefschetz Theory with Twisted Coefficients [PDF]

, 2014
The monodromy action in the homology (generally with twisted coefficients) of complements of stratified complex analytic varieties depending on parameters is studied.
Vassiliev, Victor A.
core  

Geometric conditions for $\square$-irreducibility of certain representations of the general linear group over a non-archimedean local field

, 2017
Let $\pi$ be an irreducible, complex, smooth representation of $GL_n$ over a local non-archimedean (skew) field. Assuming $\pi$ has regular Zelevinsky parameters, we give a geometric necessary and sufficient criterion for the irreducibility of the ...
Lapid, Erez, Minguez, Alberto
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source