Results 41 to 50 of about 183,894 (263)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Local convergence of the Gauss-Newton-Kurchatov method under generalized Lipschitz conditions

Karpatsʹkì Matematičnì Publìkacìï, 2021
We investigate the local convergence of the Gauss-Newton-Kurchatov method for solving nonlinear least squares problems. This method is a combination of Gauss-Newton and Kurchatov methods and it is used for problems with the decomposition of the operator.
S.M. Shakhno, H.P. Yarmola
doaj   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

Convergence and Dynamics of Schröder’s Method for Zeros of Analytic Functions with Unknown Multiplicity

Mathematics
In this paper, we investigate the local convergence of Schröder’s method for finding zeros of analytic functions with unknown multiplicity. Thus, we obtain a convergence theorem that provides exact domains of initial points together with error estimates ...
Plamena I. Marcheva, Stoil I. Ivanov
doaj   +1 more source

Network Localization of Fatigue in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Fatigue is among the most common symptoms and one of the main factors determining the quality of life in multiple sclerosis (MS). However, the neurobiological mechanisms underlying fatigue are not fully understood. Here we studied lesion locations and their connections in individuals with MS, aiming to identify brain networks ...
Olli Likitalo, Jaakko Kungshamn, Albert Bellmunt‐Gil, Silvia Tommasin, Abhineet Ojha, Matias Viitala, Juho Aaltonen, Jyrki Lötjönen, Juha Koikkalainen, Pauli Ylikotila, Patrizia Pantano, Merja Soilu‐Hänninen, Juho Joutsa   +12 more
wiley   +1 more source

Convergence of locally homogeneous spaces [PDF]

Geometriae Dedicata, 2020
We study three different topologies on the moduli space $\mathscr{H}^{\rm loc}_m$ of equivariant isometry classes of $m$-dimensional locally homogeneous Riemannian spaces. As an application, we provide the first examples of locally homogeneous spaces converging to a limit space in the pointed $\mathcal{C}^{k, }$-topology, for some $k>1$, which do ...
openaire   +4 more sources

Local homeomorphisms via ultrafilter convergence [PDF]

Proceedings of the American Mathematical Society, 2004
A continuous mapping \(f\) from a \(\lambda\)-space \(X\) (a space \(X\)) into a space \(Y\) is a local homeomorphism if and only if it is a (pullback-stable) discrete fibration. \(f\) is a discrete fibration if for each \(x\in X\) and each ultrafilter \(\xi\) converging to \(f(x)\) in \(Y\), there is a unique ultrafilter \(\eta\) converging to \(x ...
Clementino, Maria Manuel, Hofmann, Dirk, Janelidze, George   +2 more
openaire   +3 more sources

Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz, Josefine Eck, Joel S. Winston, Kate Baker   +3 more
wiley   +1 more source