Results 51 to 60 of about 6,928,094 (298)
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Least Change Secant Update Methods for Nonlinear Complementarity Problem
Ingeniería y Ciencia, 2015 In this work, we introduce a family of Least Change Secant Update Methods for solving Nonlinear Complementarity Problems based on its reformulation as a nonsmooth system using the one-parametric class of nonlinear complementarity functions introduced by ...
Favián Arenas A +2 more
doaj +1 more source
Local convergence of generalized Mann iteration [PDF]
Numerical Algorithms, 2017 The article deals with generalized Mann iterations \[ x_{n+1} = (I - D_n)x_n + D_nT(x_n), \qquad n = 0,1,2,\ldots,\eqno(1) \] for the approximative construction of fixed points of a nonlinear operator \(T:\;C \to H\), where \(H\) is a real Hilbert space, \(C\) an open subset of \(H\), \(\{D_n\} \subset L(H)\) is a generalized control sequence.
Stefan Maruster, Laura Maruster
openaire +4 more sources
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Local convergence of the Gauss-Newton-Kurchatov method under generalized Lipschitz conditions
Karpatsʹkì Matematičnì Publìkacìï, 2021 We investigate the local convergence of the Gauss-Newton-Kurchatov method for solving nonlinear least squares problems. This method is a combination of Gauss-Newton and Kurchatov methods and it is used for problems with the decomposition of the operator.
S.M. Shakhno, H.P. Yarmola
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Nonlinear Stochastic Convergence Analysis of Regional Unemployment Rates in Poland [PDF]
This paper analyzes convergence of unemployment rates in Poland at the local level by testing nonlinear convergence, applying the modified KSS-CHLL test for each pair of territorial units.
Piotr Wojcik, Joanna Tyrowicz
core +2 more sources