Results 61 to 70 of about 6,698,594 (332)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Kernel convergence of hyperbolic components. [PDF]
, 1997 We study families $G(\lambda,\cdot)$ of entire functions that are approximated by a sequence of families $G_n(\lambda,\cdot)$ of entire functions, where $\lambda\in\C$ is a parameter.
Krauskopf, B. +5 more
core +1 more source
Local convergence of the Gauss-Newton-Kurchatov method under generalized Lipschitz conditions
Karpatsʹkì Matematičnì Publìkacìï, 2021 We investigate the local convergence of the Gauss-Newton-Kurchatov method for solving nonlinear least squares problems. This method is a combination of Gauss-Newton and Kurchatov methods and it is used for problems with the decomposition of the operator.
S.M. Shakhno, H.P. Yarmola
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Local convergence of generalized Mann iteration [PDF]
Numerical Algorithms, 2017 The article deals with generalized Mann iterations \[ x_{n+1} = (I - D_n)x_n + D_nT(x_n), \qquad n = 0,1,2,\ldots,\eqno(1) \] for the approximative construction of fixed points of a nonlinear operator \(T:\;C \to H\), where \(H\) is a real Hilbert space, \(C\) an open subset of \(H\), \(\{D_n\} \subset L(H)\) is a generalized control sequence.
Stefan Maruster, Laura Maruster
openaire +3 more sources
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Astrocyte heterogeneity in brain metastases
Molecular Oncology, EarlyView.Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver +2 more
wiley +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Nonlinear Stochastic Convergence Analysis of Regional Unemployment Rates in Poland [PDF]
This paper analyzes convergence of unemployment rates in Poland at the local level by testing nonlinear convergence, applying the modified KSS-CHLL test for each pair of territorial units.
Piotr Wojcik, Joanna Tyrowicz
core +4 more sources