Results 61 to 70 of about 6,928,094 (298)

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

open access: yesMolecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas   +16 more
wiley   +1 more source

Convergence Analysis and Complex Geometry of an Efficient Derivative-Free Iterative Method

open access: yesMathematics, 2019
To locate a locally-unique solution of a nonlinear equation, the local convergence analysis of a derivative-free fifth order method is studied in Banach space.
Deepak Kumar   +2 more
doaj   +1 more source

On C-To-R-Based Iteration Methods for a Class of Complex Symmetric Weakly Nonlinear Equations

open access: yesMathematics, 2020
To avoid solving the complex systems, we first rewrite the complex-valued nonlinear system to real-valued form (C-to-R) equivalently. Then, based on separable property of the linear and the nonlinear terms, we present a C-to-R-based Picard iteration ...
Min-Li Zeng, Guo-Feng Zhang
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

Convergence analysis of a power series based iterative method having seventh order of convergence

open access: yesМатематичні Студії
In this paper, we propose a new three-point iterative scheme for solving nonlinear equations, which achieves seventh-order convergence. The method begins with a standard Newton iteration, followed by two weighted-Newton steps constructed using power ...
C. D. Sreedeep   +4 more
doaj   +1 more source

Local convergence of some high order iterative methods based on the decomposition technique using only the first derivative [PDF]

open access: yesSurveys in Mathematics and its Applications, 2017
We present a local convergence analysis of some high order iterative methods based on the decomposition technique using only the first derivative for solving equations in order to approximate a solution of a nonlinear equation.
Ioannis K. Argyros, Santhosh George
doaj  

Convergence Analysis of a Three Step Newton-like Method for Nonlinear Equations in Banach Space under Weak Conditions

open access: yesAnnals of the West University of Timisoara: Mathematics and Computer Science, 2016
In the present paper, we study the local convergence analysis of a fifth convergence order method considered by Sharma and Guha in [15] to solve equations in Banach space.
Argyros Ioannis K., George Santhosh
doaj   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

open access: yesMolecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David   +12 more
wiley   +1 more source

Sigma-Convergence Versus Beta-Convergence: Evidence from U.S. County-Level Data [PDF]

open access: yes
In this paper we outline (i) why ó-convergence may not accompany â- convergence, (ii)cite evidence of â-convergence in the U.S., (iii) and use USA county-level data containing over 3,000 cross-sectional observations to demonstrate that ó-convergence does
Daniel Levy   +2 more
core   +2 more sources

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