Results 41 to 50 of about 220,118 (258)
Mathematics, 2019 The foremost aim of this paper is to suggest a local study for high order iterative procedures for solving nonlinear problems involving Banach space valued operators. We only deploy suppositions on the first-order derivative of the operator.
Ramandeep Behl +2 more
doaj +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Local convergence of a two-step Gauss-Newton Werner-type method for solving least squares problems
Journal of Numerical Analysis and Approximation TheoryThe aim of this paper is to extend the applicability of a two-step Gauss-Newton-Werner-type method (TGNWTM) for solving nonlinear least squares problems.
Ioannis K. Argyros, Santhosh George
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Least Change Secant Update Methods for Nonlinear Complementarity Problem
Ingeniería y Ciencia, 2015 In this work, we introduce a family of Least Change Secant Update Methods for solving Nonlinear Complementarity Problems based on its reformulation as a nonsmooth system using the one-parametric class of nonlinear complementarity functions introduced by ...
Favián Arenas A +2 more
doaj +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Local convergence of generalized Mann iteration [PDF]
Numerical Algorithms, 2017 The article deals with generalized Mann iterations \[ x_{n+1} = (I - D_n)x_n + D_nT(x_n), \qquad n = 0,1,2,\ldots,\eqno(1) \] for the approximative construction of fixed points of a nonlinear operator \(T:\;C \to H\), where \(H\) is a real Hilbert space, \(C\) an open subset of \(H\), \(\{D_n\} \subset L(H)\) is a generalized control sequence.
Stefan Maruster, Laura Maruster
openaire +4 more sources
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source