Results 101 to 110 of about 27,502,073 (401)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Local Economic Development Policies [PDF]

open access: yes
This chapter seeks to provide useful advice for local government policy towards economic development programs. The chapter: reviews the size and scope of local economic development programs in the United States; critically analyzes the various rationales
Timothy J. Bartik
core   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

open access: yesFEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Malaysian local governments’ role towards sustainable development focusing on knowledge transfer practices framework [PDF]

open access: yes, 2014
Local Governments are facing very demanding and dynamic situation in development agenda when dealing with sustainable development. When the development’s activities do not start with the sustainability elements at Local Governments, the negative ...
Mohamed, Sulzakimin
core  

Entrepreneurial in-migrants and economic development in rural England [PDF]

open access: yes, 2008
Counterurbanisation has generally been viewed as a negative phenomenon, but Stockdale and Findlay (2004) presented rural in-migration as potentially “a catalyst for economic regeneration” based on in-migrants’ business activity.
Bosworth, Gary
core   +1 more source

Multidisciplinary nursing practice in a low-resource setting in Southeast Brazil

open access: yesHealthcare in Low-resource Settings
The various specializations available to nurses represent an investment geared toward providing more qualified patient care. However, little is known about the attitudes of specialized nurses toward multidisciplinarity.
Bruno Henrique Souza Izidório   +4 more
doaj   +1 more source

Sustainable Local Development and Environmental Governance: A Strategic Planning Experience

open access: yes, 2016
The emphasis on learning and adaptation among different actors at various political administrative levels and on various geographic scales has become a precondition for the emergence of sustainable development.
G. Ioppolo   +4 more
semanticscholar   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

open access: yesFEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Local innovation systems in Poland - the beginning of the road

open access: yesMiscellanea Geographica: Regional Studies on Development, 2017
Local innovation systems (LIS) constitute a relatively new term as usually the discussion about the systemic approach to innovation has focused on the level of countries, and most of all - regions.
Dziemianowicz Wojciech   +2 more
doaj   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

open access: yesFEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

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