Results 121 to 130 of about 9,120,391 (361)

Ibero-American Research on Local Development. An Analysis of Its Evolution and New Trends [PDF]

open access: yes, 2019
Local development is a subject that arouses significant interest in the international scientific community in general, and in the Ibero-American one, in particular.
Pablo Valenciano, Jaime de   +3 more
core   +1 more source

The role of universities in local development

open access: yesCorvinus Journal of Sociology and Social Policy, 2014
The paper deals with the role that universities can have in promoting innovation in general and at local and regional level in particular. In doing this, the nature of universities and the quality of their relations to industry and governments is of paramount importance. During the last three decades university-industry relationships and the supportive
openaire   +3 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Development expenditures and the local financing constraint [PDF]

open access: yes
Focusing on the local financing constraint sheds new light on issues of aid, fiscal reform, and the management of public spending. The fungibility of aid need not translate into resource flows to fill the local financing gap.
Agbonyitor, Albert D. K.
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Deformation Control for Foundation Pit Segmented Construction Adjacent to Operational High-speed Railway Lines

open access: yesChengshi guidao jiaotong yanjiu
Objective Limited land use resource and arrangement adjacent to operational high-speed railway lines pose significant challenges to some city foundation pit constructions and the railway operational safety.
LI Xiaolong   +5 more
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Preferential allosteric modulation of Otop1 channels by small molecule compounds

open access: yesCommunications Biology
The Otopetrin (Otop) proteins, comprising Otop1-3, are proton-gated proton channels with key biological functions. Otop1 acts as a receptor for sour and ammonium salt tastes in mammals, but its gating mechanisms and pharmacology remain poorly understood.
Xiangjin Kong   +10 more
doaj   +1 more source

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