Results 161 to 170 of about 3,027,964 (314)

Local Action Groups in the Autonomous Provinces of Trento and Bolzano - Bozen: administrators of European funds or agencies of local development on the territory

, 2023
reservedThis thesis focuses on the LEADER Programme of the European Union, particularly on Local Action Groups in the Autonomous Provinces of Trento and Bolzano – Bozen in Northern Italy.
BELDI', MADDALENA
core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Amazonia Bond Issuance Guidelines: Guidance for Labeled Bonds Dedicated to Financing the Economic, Environmental, and Social Development of the Amazonia Region

The Inter-American Development Bank and the World Bank jointly developed the Amazonia Bond Issuance Guidelines to provide guidance and suggestions for the issuance of capital market instruments to finance investments in projects that support the ...
Inter-American Development Bank
core   +1 more source

Impact of Shopping Tourism for the Retail Trade as a Strategy for the Local Development of Cities. [PDF]

Front Psychol, 2020
Muro-Rodríguez AI, Pérez-Jiménez IR, Sánchez-Araque JA.   +2 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

An Introduction to Food Cooperatives in the Bekaa Valley, Lebanon: Territorial Actors and Potential Levers to Local Development Through Culinary Heritage. [PDF]

Food Ethics, 2020
Jalkh R, Dedeire M, Requier Desjardins M.   +2 more
europepmc   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Economies of Scale and Efficiency in the Wastewater Treatment Sector: A Decision Tree Approach

Applied Sciences
In this study, we use the efficiency analysis trees (EAT) model to evaluate the efficiency of wastewater treatment plants (WWTPs), focusing on identifying the key variables that enhance their performance.
Vicent Hernández-Chover, Águeda Bellver-Domingo, Lledó Castellet-Viciano, Francesc Hernández-Sancho   +3 more
doaj   +1 more source

Towards a Sustainable Local Development of Instructional Material: An Impact Assessment of Locally Produced Videos on EFL Learners' Skills and Individual Difference Factors. [PDF]

Front Psychol, 2020
Lasekan O, Godoy M.
europepmc   +1 more source