Results 151 to 160 of about 9,120,391 (361)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Clusters and Factors that Form the Dimensions of Local Development

, 2022
Roseane Grossi Silva, Dante Pinheiro Martinelli   +1 more
openalex   +1 more source

Developmental Education: The Value of High Quality Preschool Investments as Economic Tools [PDF]

, 2004
This working paper is among a series of papers funded by the Pew Charitable Trusts through its "Advancing Quality Pre-K for All" initiative. The paper finds that early childhood education appears to offer great potential returns and low risks, and should

core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Roles of Cooperative Societies in Aquaculture Development: A Case Study of Some Local Government Areas in Rivers State, Nigeria

, 2018
OA Akinrotimi
openalex   +2 more sources

Territorial identity as a strategic resource for the development of rural areas [PDF]

, 2015
Rural areas play a relevant role in the EU: their specific ecosystems, landscapes and cultures are a highly valuable treasure, which could be lost if the trends of social, economic and demographic marginalization characterizing many of them are not ...
Banini, Tiziana, Pollice, Fabio
core  

An Introduction to Food Cooperatives in the Bekaa Valley, Lebanon: Territorial Actors and Potential Levers to Local Development Through Culinary Heritage. [PDF]

Food Ethics, 2020
Jalkh R, Dedeire M, Requier Desjardins M.   +2 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Economies of Scale and Efficiency in the Wastewater Treatment Sector: A Decision Tree Approach

Applied Sciences
In this study, we use the efficiency analysis trees (EAT) model to evaluate the efficiency of wastewater treatment plants (WWTPs), focusing on identifying the key variables that enhance their performance.
Vicent Hernández-Chover, Águeda Bellver-Domingo, Lledó Castellet-Viciano, Francesc Hernández-Sancho   +3 more
doaj   +1 more source

Local Public Policy and the Residential Development Process [PDF]

, 1967
Kaiser, Edward J., Weiss, Shirley F.
core   +2 more sources