Results 81 to 90 of about 27,502,073 (401)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Public sector restructuring and regional development: the impact of compulsory competitive tendering in the UK [PDF]

, 2002
This paper contributes to the analysis of contemporary public sector restructuring in the UK through an evaluation of the impact of the introduction of compulsory competitive tendering (CCT) for the provision of local public services.
Patterson, A., Pinch, P. L.
core   +1 more source

Inherent fast inactivation particle of Nav channels as a new binding site for a neurotoxin

The EMBO Journal
Neurotoxins derived from animal venoms are indispensable tools for probing the structure and function of voltage-gated sodium (Nav) channels. Utilizing a novel centipede peptide toxin called rpTx1, we show that the “inherent inactivation particle” of Nav
Xi Zhou, Haiyi Chen, Shuijiao Peng, Yuxin Si, Gaoang Wang, Li Yang, Qing Zhou, Minjuan Lu, Qiaoling Xie, Xi He, Meijing Wu, Xin Xiao, Xiaoqing Luo, Xujun Feng, Wenxing Wang, Sen Luo, Yaqi Li, Jiaxin Qin, Minzhi Chen, Qianqian Zhang, Weijun Hu, Songping Liang, Tingjun Hou, Zhonghua Liu   +23 more
doaj   +1 more source

National Innovation System (NIS) as a Means for Development: Policies, Opportunities, and Challenges in Ethiopia. [version 2; peer review: 2 approved, 1 approved with reservations]

F1000Research
Introduction A robust National Innovation System (NIS) has become crucial for fostering socioeconomic progress and competitiveness in emerging economies like Ethiopia, and its success relies significantly on successful implementation of science ...
Ashenafi Bayinesagn, Filimon Hando, Tegegn Belay, Kassahun Sube   +3 more
doaj   +1 more source

Higher education contributing to local, national, and global development: new empirical and conceptual insights

Higher Education, 2020
Higher education offers the potential to support glonacal (global, national, and local) development. This study presents new empirical and conceptual insights into the ways in which higher education can help to achieve and exceed the outcomes enshrined ...
M. Chankseliani, I. Qoraboyev, D. Gimranova   +2 more
semanticscholar   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Local market development for Shan Yuan Chinese Restaurant [PDF]

, 2018
Shan Yuan Chinese Restaurant (SYCR) is a Chinese restaurant located at 228 Victoria Street, Hamilton. As the most sinological Chinese restaurants in Hamilton, SYCR has always tried to provide customers with the best service and food.
Maqbool, Jannat, Yue, Chuan
core  

A Scorpion Peptide Exerts Selective Anti-Leukemia Effects Through Disrupting Cell Membranes and Triggering Bax/Bcl-2-Related Apoptosis Pathway

Biomolecules
Numerous modern scientific studies have demonstrated that animal venoms harbor a wealth of diverse anticancer active components, serving as a valuable resource for the development of natural antitumor drugs.
Xiaoping Dong, Siwei Yi, Yaqin Yang, Yushuo Wang, Lingxiang Wang, Jingjing Huang, Yong Zeng, Zhonghua Liu   +7 more
doaj   +1 more source

Challenges in local governance: Public-private partnerships as an instrument for local transport policies

Studia z Polityki Publicznej, 2020
Public-private partnerships (PPP) as suppliers for public services have been increasingly used as an instrument for improving public policy, mostly when it comes to reducing costs and improving public transport.
Everardo Chiapa Aguillón
doaj   +1 more source