Results 111 to 120 of about 10,043,064 (337)

Orodental Local Drug Delivery

Journal of Health Sciences & Research, 2015
ABSTRACTOral mucosal diseases are the most common diseases affecting humans and these can be treated with the use of various drugs. These drugs can be administered via many routes to produce its pharmacological bioeffects. One such site is the oral cavity, where both local and systemic deliveries of drug can take place.
Nandita Ahanthem, Nikhat Gazge
openaire   +1 more source

Preparation, characterization and dissolution studies of pharmaceutical co-crystals containing indomethacin

, 2013
Purpose: To change the dissolution properties of indomethacin, a non-steroidal anti-inflammatory drug characterized by weak solubility and bioavailability, we propose the preparation of co-crystals where the active pharmaceutical ingredient is ...
DALPIAZ, Alessandro, BERTOLASI, Valerio, FERRETTI, Valeria   +2 more
core  

Local Drug Delivery to Bone Joints with Microspheres [PDF]

, 2019
The concept of local drug delivery in the form of microspheres has potential for use as an alternative to conventional therapy strategies in the treatment of pain and inflammatory symptoms in case of certain bone and joint diseases.
Soundrapandian, Chidambaram, Poudyal, Adarsh Pratik   +1 more
core   +1 more source

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source

Primary and novel approaches for colon targeted drug delivery – A review [PDF]

, 2010
The colon is a site where both local and systemic delivery of drugs can take place. Local delivery could, for example, allow topical treatment of inflammatory bowel disease.
Pranay Wal, Ankita Wal, Gaurav Tiwari, Ruchi Tiwari, Awani K. Rai   +4 more
core  

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Safety and Tolerability of Givinostat: Evidence From Real‐World and Clinical Practice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The aim of our study was to establish the prevalence of adverse events in a real‐world setting in boys living with Duchenne muscular dystrophy (DMD) treated with givinostat as part of an Expanded Access Program (EAP) in Italy. Methods The cohort included 90 ambulant boys, with age when treatment started between 6 and 23 years (mean ...
Marika Pane, Anna Capasso, Chiara Arpaia, Adele D’Amico, Emilio Albamonte, Federica Trucco, Maria Sframeli, Riccardo Masson, Francesca Magri, Luca Bello, Romina Venditti, Claudia Dosi, Michela Catteruccia, Michele Tosi, Claudio Bruno, Sonia Messina, Giacomo Comi, Elena Pegoraro, Valeria A. Sansone, Eugenio Mercuri   +19 more
wiley   +1 more source

Recent Advances in Drug Delivery from the Oral Cavity. Focus on innovative buccal drug delivery devices

, 2011
In this report, the drug administration via the oral cavity is discussed. Regional variations in oral mucosae, drug delivery via the keratinised mucosae for local treatment, and drug delivery via the not keratinised mucosae for local and systemic ...
PADERNI, Carlo, GIANNOLA, Libero Italo
core  

Osmotic drug delivery system: A review [PDF]

, 2019
Osmotic drug delivery uses the osmotic pressure level for controlled delivery of drugs by using osmogens. Osmotic systems for controlled drug-delivery applications are well established, both in human pharmaceuticals and in veterinary medicine.
Palanisamy, P., Chandira, R. Margret, Venkateswarlu, B.S., Pasupthi, A., Margret Chandira, R., Pasupathi, C., Jaykar, B., Pasupathi, A.   +7 more
core   +1 more source

Investigation and Evaluation of the Transdermal Delivery of Ibuprofen in Various Characterized Nano-Drug Delivery Systems

, 2023
The aim was to assess the suitability of three nano-based transdermal drug delivery systems containing ibuprofen: a nano-emulsion, a nano-emulgel, and a colloidal suspension with ibuprofen-loaded nanoparticles.
Jeanri Myburgh, Admire Dube, Minja Gerber, Wilna Liebenberg, Clarissa Willers   +4 more
core   +1 more source