Results 91 to 100 of about 10,043,064 (337)

Formulation and Evaluation of Colon Targeted Oral Drug Delivery Systems for Metronidazole in Treatment of Amoebiasis [PDF]

, 2011
The aim of present study was to develop colon targeted system for metronidazole using guar gum and xanthan gum. Matrix formulations containing various proportions of guar gum and xanthan gum were prepared by wet granulation technique using 10% starch ...
Singh, Shailendra K; Division of Drug Delivery and Research, Department of Pharmaceutical Sciences, Guru Jambeshwar University of Science and Technology, Hisar-125001, (Haryana)-India, Gauri, Bhawna; Division of Drug Delivery and Research, Department of Pharmaceutical Sciences, Guru Jambeshwar University of Science and Technology, Hisar-125001, (Haryana)-India, Mishra, DinaNath; Division of Drug Delivery and Research, Department of Pharmaceutical Sciences, Guru Jambeshwar University of Science and Technology, Hisar-125001, (Haryana)-India   +2 more
core  

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Drug leakage limits intratumoral drug exposure and efficacy: Influence of tumor mechanical heterogeneity

Pharmacological Research
Intratumoral administration is widely used to achieve high local drug delivery while minimizing systemic toxicity. However, the fundamental assumption that locally injected agents remain within tumor tissue has rarely been quantitatively examined.
Kazuhiro Terai, Ryusho Kariya, Hiromi Ogata-Aoki, Mariko Ogura, Hiromitsu Iga, Satoshi Sakamoto, Seiji Sakano, Seiji Okada   +7 more
doaj   +1 more source

Drug Delivery Approaches for the Treatment of Cervical Cancer

Pharmaceutics, 2016
Cervical cancer is a highly prevalent cancer that affects women around the world. With the availability of new technologies, researchers have increased their efforts to develop new drug delivery systems in cervical cancer chemotherapy. In this review, we
Farideh Ordikhani, Mustafa Erdem Arslan, Raymundo Marcelo, Ilyas Sahin, Perry Grigsby, Julie K. Schwarz, Abdel Kareem Azab   +6 more
doaj   +1 more source

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

Solubility enhancement and application of cyclodextrins in local drug delivery

Journal of Pharmaceutical Investigation, 2019
Cyclodextrins (CDs) have been used in many pharmaceutical formulations as their constitution and inherent shape present advantages for drugs with poor aqueous solubility and low bioavailability.
Dong-Hyun Kim, Sang-Eun Lee, Yong-Chul Pyo, Phuong Tran, Jeong-Sook Park   +4 more
semanticscholar   +1 more source

Service delivery review: a how to manual for local government [PDF]

, 2014
This resource aims to assist councils assess the services they provide for local communities. Service Delivery Review: A How to Manual for Local Government brings together advice, toolkits and templates to help councils regardless of size ...
Roberta Ryan, SallyAnn Hunting, Tim Robinson, Hunting, SA, Ryan, R, Robinson, T   +5 more
core  

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

Current strategies for drug delivery to the inner ear

Acta Pharmaceutica Sinica B, 2013
For many years, drug delivery to the inner ear has been a challenge to physicians in the treatment of inner ear disorders. In the past decade, the field of inner ear drug delivery has emerged with the development of new biomaterials and drug delivery ...
Hongzhuo Liu, Jinsong Hao, Kevin S. Li
doaj   +1 more source

Fibrin glue as a local drug-delivery system for bacteriophage PA5

Scientific Reports, 2019
Fibrin glue has been used clinically for decades in a wide variety of surgical specialties and is now being investigated as a medium for local, prolonged drug delivery.
Evgenii Rubalskii, S. Ruemke, C. Salmoukas, A. Aleshkin, Svetlana I. Bochkareva, E. Modin, Bakr Mashaqi, Erin C. Boyle, D. Boethig, M. Rubalsky, E. Zulkarneev, C. Kuehn, A. Haverich   +12 more
semanticscholar   +1 more source