Results 71 to 80 of about 10,043,064 (337)

Advancements in Rectal Drug Delivery Systems: Clinical Trials, and Patents Perspective

, 2022
The rectal route is an effective route for the local and systemic delivery of active pharmaceutical ingredients. The environment of the rectum is relatively constant with low enzymatic activity and is favorable for drugs having poor oral absorption ...
Vishvakarma, Vivekanand, Sangnim, Tanikan, Tanikan Sangnim, Inderbir Singh, Vivekanand Vishvakarma, Huanbutta, Kampanart, Rathi, Ritu, Singh, Inderbir, Alpesh Kumar, Kumar, Alpesh, Sanshita, Ritu Rathi, Sanshita,, Kampanart Huanbutta   +13 more
core   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Overcoming therapeutic challenges in acute myeloid leukemia: active targeting strategies by nano-drug delivery systems

Journal of Translational Medicine
Background Acute myeloid leukemia (AML) is a highly aggressive hematological malignancy characterized by poor overall survival and high relapse rates.
Yuqian Tang, Jiaxin Li, Wu Ye, Yiwen Du, Ying Zhang, Yunxia Ye, Yuping Gong   +6 more
doaj   +1 more source

Advances in Drug Delivery via Biodegradable Ureteral Stent for the Treatment of Upper Tract Urothelial Carcinoma

Frontiers in Pharmacology, 2020
Drug eluting ureteral stent is an effective means for local drug delivery to the urinary tract. It can potentially solve a variety of upper urinary tract problems, such as stent-related urinary tract infections and discomfort, ureteral stricture, and ...
Hongli Shan, Zhongshuai Cao, Changliang Chi, Jixue Wang, Xiaoqing Wang, Jingyan Tian, Bing Yu   +6 more
doaj   +1 more source

Nucleoside‐Based Self‐Assembling Drugs for Localized Drug Delivery [PDF]

ChemMedChem, 2018
AbstractWe have synthesized a range of gelators based on the nucleoside analogues gemcitabine and lamivudine, characterizing representative gels from the series using rheology and transmission electron microscopy. Growth inhibition studies of gemcitabine derivatives confirmed the feasibility of these compounds as novel treatments, indicating the ...
Kathryn J. Skilling, Michael J. Stocks, Barrie Kellam, Marianne Ashford, Tracey D. Bradshaw, Laurence Burroughs, Maria Marlow   +6 more
openaire   +2 more sources

Precise Design Strategies of Nanotechnologies for Controlled Drug Delivery

, 2022
Rapid advances in nanotechnologies are driving the revolution in controlled drug delivery. However, heterogeneous barriers, such as blood circulation and cellular barriers, prevent the drug from reaching the cellular target in complex physiologic ...
Shiyi Huang, Huang, Shiyi, Ding, Xianting, Xianting Ding   +3 more
core   +1 more source

Mitochondrial translation and coordinated cytosolic translation in metabolic homeostasis and disease

FEBS Letters, EarlyView.
Mitochondrial function depends on coordinated protein production from the nuclear and mitochondrial genomes. This review highlights how cytosolic and mitochondrial translation, mRNA localization, protein import, and respiratory complex assembly are integrated to maintain mitochondrial proteostasis and function.
Boseon Kim, Thi Thanh Mai Tran, Nakyung Kang, Min‐Woo Lee, Mihye Lee   +4 more
wiley   +1 more source

Chewing Gums as a Drug Delivery Approach for Oral Health

International Journal of Dentistry, 2022
Background. Drug delivery approaches with the shortest therapeutic period and the lowest side effects have always been considered a sublime target in the medical sciences.
Morteza Banakar, Sedigheh Moayedi, Erfan Shamsoddin, Zahra Vahedi, Mohammad Hasan Banakar, Seyyed Mojtaba Mousavi, Dinesh Rokaya, Kamran Bagheri Lankarani   +7 more
doaj   +1 more source

A tunable and injectable local drug delivery system for personalized periodontal application.

Journal of Controlled Release, 2020
In periodontal treatment, patient differences in disease phenotype and treatment responses are well documented. Therefore, therapy duration and dosage should be tailored to the requirements of individual patients.
Bing Wang, Jia-Mian Wang, Jinlong Shao, P. Kouwer, E. Bronkhorst, J. Jansen, X. Walboomers, F. Yang   +7 more
semanticscholar   +1 more source