Results 101 to 110 of about 10,043,064 (337)

Micro and nanoscale technologies in oral drug delivery [PDF]

, 2020
Oral administration is a pillar of the pharmaceutical industry and yet it remains challenging to administer hydrophilic therapeutics by the oral route.
Nasiri, R, Hosseini, Vahid, Nasrollahi, F, Desai, Tejal A., Mofidfar, Mohammad, Khademhosseini, Ali, Nasrollahi, Fatemeh, Finbloom, JA, Montazerian, Hossein, Montazerian, H, Stevens, Molly M, Ahadian, S, Davoodi, E, Nasiri, Rohollah, Fetah, K, Stevens, Molly M., Emir Diltemiz, Sibel, Sangabathuni, S, Dokmeci, Mehmet Remzi, Finbloom, Joel A, Diltemiz, Sibel Emir, Stevens, Molly, Finbloom, Joel A., Desai, TA, Ahadian, Samad, Mofidfar, M, Hosseini, V, Davoodi, Elham, Sangabathuni, Sivakoti, Fetah, Kirsten, Mylonaki, Ioanna, Desai, Tejal A, Khademhosseini, A, Remzi Dokmeci, Mehmet, Mylonaki, I, Remzi Dokmeci, M   +35 more
core   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Implantable Antimicrobial Biomaterials for Local Drug Delivery in Bone Infection Models

Acta Biomaterialia, 2019
Increased use of implantable biomedical devices demonstrates their potential in treating a wide variety of ailments and disorders in bone trauma and orthopaedic, reconstructive, and craniofacial applications.
J. Caplin, Andrés J. García
semanticscholar   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Cryo-EM structures of ryanodine receptors and diamide insecticides reveal the mechanisms of selectivity and resistance

Nature Communications
The resistance of pests to common insecticides is a global issue that threatens food production worldwide. Diamide insecticides target insect ryanodine receptors (RyRs), causing uncontrolled calcium release from the sarcoplasmic and endoplasmic reticulum.
Lianyun Lin, Changshi Wang, Wenlan Wang, Heng Jiang, Takashi Murayama, Takuya Kobayashi, Hadiatullah Hadiatullah, Yu Seby Chen, Shunfan Wu, Yiwen Wang, Henryk Korza, Yucheng Gu, Yan Zhang, Jiamu Du, Filip Van Petegem, Zhiguang Yuchi   +15 more
doaj   +1 more source

Biomaterial-based Drug delivery strategies for head and neck cancer: Local delivery, combination therapy, and translational challenges

International Journal of Pharmaceutics: X
Head and neck cancer, particularly head and neck squamous cell carcinoma, remains difficult to treat because of local recurrence, treatment-related morbidity, and the limited efficacy of systemic drug delivery.
Chang Li, Yuan Liu, Zhifeng Wen, Junxiong Wen, Xiao Cui, Xue Zhang   +5 more
doaj   +1 more source

Exploring the Therapeutic Synergy of Quercetin Gel and Mechanical Debridement in Periimplantitis Management: A Prospective Clinical Evaluation [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Peri-implantitis is a chronic inflammatory disorder characterized by continuous bone loss around dental implants, endangering their stability and long-term function.
Mohamed Thaha, Arvina Rajasekar
doaj   +1 more source

Recent advances in musculoskeletal local drug delivery

Acta Biomaterialia, 2019
Musculoskeletal disorders are a significant burden on the global economy and public health. Advanced drug delivery plays a key role in the musculoskeletal field and holds the promise of enhancing the repair of degenerated and injured musculoskeletal ...
Shi-Chao Zhang, Malcolm Xing, Bing-Yun Li   +2 more
semanticscholar   +1 more source