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Self-assembling peptides as vectors for local drug delivery and tissue engineering applications.

Advanced Drug Delivery Reviews, 2021
Molecular self-assembly has forged a new era in the development of advanced biomaterials for local drug delivery and tissue engineering applications. Given their innate biocompatibility and biodegradability, self-assembling peptides (SAPs) have come in ...
C. Karavasili, D. Fatouros
semanticscholar   +1 more source

Optimizing drugs for local delivery

Drug News & Perspectives, 2009
An international panel of speakers together with approximately 70 delegates were brought together by The Society for Medicines Research's symposium on Optimising Drugs for Local Delivery, held on June 11, 2009 at the Novartis Institutes for Biomedical Research, Horsham, UK.
Collingwood, S., Lock, R., Searcey, Mark
openaire   +2 more sources

Printable Metal-Polymer Conductors for Local Drug Delivery.

Nano letters (Print), 2022
Safe and effective local drug delivery is challenging due to complex physiological barriers that limit the entry of drugs. Here, we report the metal-polymer conductors (MPCs) for local drug delivery via iontophoresis or electroporation.
Ning Ren   +3 more
semanticscholar   +1 more source

Recent Advances in Injectable Hydrogels for Controlled and Local Drug Delivery

Advanced Healthcare Materials, 2020
Injectable hydrogels have received considerable interest in the biomedical field due to their potential applications in minimally invasive local drug delivery, more precise implantation, and site‐specific drug delivery into poorly reachable tissue sites ...
Fabio Rizzo, N. S. Kehr
semanticscholar   +1 more source

Hyaluronidase overcomes the extracellular matrix barrier to enhance local drug delivery.

European journal of pharmaceutics and biopharmaceutics
The stratum corneum of the skin presents the initial barrier to transdermal penetration. The dense structure of the extracellular matrix (ECM) further impedes local drug dispersion.
Jingru Zhao   +4 more
semanticscholar   +1 more source

Biomaterial scaffold-based local drug delivery systems for cancer immunotherapy.

Science Bulletin, 2020
Immunotherapy has attracted tremendous attention due to the remarkable clinical successes for treating a broad spectrum of tumors. One challenge for cancer immunotherapy is the inability to control localization and sustain concentrations of therapeutics ...
Chen Yang   +4 more
semanticscholar   +1 more source

Local drug delivery systems for inflammatory diseases: Status quo, challenges, and opportunities.

Journal of Controlled Release, 2020
Inflammation that is not resolved in due course becomes a chronic disease. The treatment of chronic inflammatory diseases involves a long-term use of anti-inflammatory drugs such as corticosteroids and nonsteroidal anti-inflammatory drugs, often ...
Yun-Chu Chen   +4 more
semanticscholar   +1 more source

Injectable thermosensitive hydrogel-based drug delivery system for local cancer therapy.

Colloids and Surfaces B: Biointerfaces, 2021
Injectable thermosensitive hydrogel has been regarded as attractive drug delivery system, which displays a sol-gel phase transition upon injection in response to temperature.
Yin Xiao   +8 more
semanticscholar   +1 more source

Vaginal drug delivery system: A promising route of drug administration for local and systemic diseases.

Drug Discovery Today
Scientists around the globe have done cutting-edge research to facilitate the delivery of poorly absorbed drugs via various routes of administration and different delivery systems.
M. Tamil Mani Subi   +2 more
semanticscholar   +1 more source

Local drug delivery systems in the management of periodontitis: A scientific review.

Journal of Controlled Release, 2019
Periodontitis (PD) is a microbial disease of tooth supporting tissues that results in progressive destruction of surrounding soft and hard tissues with eventual tooth mobility and exfoliation.
H. R. Rajeshwari   +7 more
semanticscholar   +1 more source

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