Results 291 to 300 of about 10,043,064 (337)

Ultrasound Mediated Localized Drug Delivery

2011
Chemotherapy is one of the frontline treatments for cancer patients, but the toxic side effects limit its effectiveness and potential. The goal of drug delivery is to reduce these side effects by encapsulating the drugs in a carrier which prevents release and can circulate throughout the body causing minimal damage to the healthy tissue.
Stuart, Ibsen, Michael, Benchimol, Dmitri, Simberg, Sadik, Esener   +3 more
openaire   +2 more sources

Local drug delivery: Current applications

Progress in Cardiovascular Diseases, 1997
Catheter-based treatment of coronary artery disease has historically been based on expansion or ablating vessels. Only in the last 3 years have we had devices that allow us to choose the location to apply agents directly onto or into the arterial wall. Previous trials of pharmaceutical agents in humans have failed despite animal trials showing efficacy.
openaire   +2 more sources

3D hydroxyapatite scaffold for bone regeneration and local drug delivery applications

Journal of Drug Delivery Science and Technology, 2019
Bone tissue engineering is the technology of healing bone defects in critical clinical conditions using functional tissue-engineering substitutes. Hydroxyapatite (HAp), as a biomaterial, received extensive attention for biomedical applications in the ...
Sudip Mondal, U. Pal
semanticscholar   +1 more source

Injectable thermosensitive hydrogel systems based on functional PEG/PCL block polymer for local drug delivery.

Journal of Controlled Release, 2019
Injectable in situ thermosensitive hydrogels have potential applications in tissue engineering and drug delivery. The hydrogel formulations exist as aqueous solutions at room temperature but rapidly solidify into gels at 37 °C in situ, making them highly
Hong-Zhang Deng, An-Jie Dong, Ji-Bin Song, X. Chen   +3 more
semanticscholar   +1 more source

Actively controlled local drug delivery using conductive polymer-based devices

, 2020
Localized and actively controlled delivery of drugs presents an opportunity for improving bioavailability, therapeutic efficacy, and long-term treatment of injury or disease.
Christopher A. R. Chapman, E. Cuttaz, J. Goding, R. Green   +3 more
semanticscholar   +1 more source

Multicompartment Hydrogels for the Local Delivery of Chemotherapic Drugs

2019
Over 85% of human cancers are solid tumors. The effectiveness of anticancer therapy in solid tumors depends on adequate delivery of the therapeutic agent to tumor cells. Inadequate delivery would result in residual tumor cells, which in turn would lead to regrowth of tumors and possibly development of resistant cells. The most prominent option, for now,
Boi S., Dellacasa E., Rouatbi N., Monticelli O., Pastorino L.   +4 more
openaire   +4 more sources

Local drug delivery to composite tissue allografts

Microsurgery, 2000
Unlike visceral solid-organ transplants, composite tissue allografts (CTA) are modules composed of various tissues, each with differing antigenicity, and therefore differing potential for rejection.1 Skin and muscle (and perhaps synovium) are the most antigenic and appear to be most susceptible to rejection, while bone, tendon, cartilage, and ...
S A, Gruber, M V, Shirbacheh, J W, Jones, J H, Barker, W C, Breidenbach   +4 more
openaire   +2 more sources

Local drug and gene delivery through microbubbles

Progress in Cardiovascular Diseases, 2001
Ultrasound contrast agents (microbubbles) lower the threshold for cavitation by ultrasound energy. Ultrasound microbubbles may be used as cavitation nuclei for drug and gene delivery. By tailoring the physical properties of microbubbles and coating materials, drugs and genetic drugs can be incorporated into ultrasound contrast agents.
E C, Unger, E, Hersh, M, Vannan, T O, Matsunaga, T, McCreery   +4 more
openaire   +2 more sources

Local drug delivery in recurrent malignant gliomas

Neurological Sciences, 2005
In recurrent malignant gliomas, we scheduled a protocol by adding to systemic temozolomide a local treatment delivered through a reservoire positioned in the surgically created cavity, consisting of either mitoxantrone, liposome-loaded doxorubicine or nimustine (ACNU). The progression-free survival (PFS) and survival time (ST) of the whole group of 112
Boiardi, A., Eoli, M., Salmaggi, A., Lamperti, E., Botturi, A., Solari, A., Di Meco, F., Broggi, G., Silvani, A.   +8 more
openaire   +3 more sources

Biomaterials for local drug delivery in central nervous system

International journal of pharmaceutics, 2019
&NA; The central nervous system (CNS) is a vital part of human body which coordinate the actions by transmitting signals. Because of the existence of the blood‐brain barrier and the blood‐spinal cord barrier, diseases in CNS can hardly be directly ...
Jia-Chen Chen, Li-Ming Li, Jian-Qing Gao
semanticscholar   +1 more source