Results 71 to 80 of about 6,425,933 (304)

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Adoption strategies of fertility-sparing surgery for early-stage cervical cancer patients based on clinicopathological characteristics: a large retrospective cohort study

Frontiers in Surgery
BackgroundThe demand for fertility-sparing surgery (FSS) is increasing among patients with early-stage cervical cancer (CC). This study aimed to evaluate the feasibility of local excision as an alternative to hysterectomy in stage I CC patients aged 15 ...
Ying Ning, Ying Ning, Xinyan Gao, Xinyan Gao, Yan Kong, Yan Wang, Tian Tian, Yu Chen, Yu Chen, Yufei Yang, Yufei Yang, Ke Lei, Zhumei Cui   +12 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Excision margins in breast conserving surgery [PDF]

, 2015
The ideal excision margin in breast conserving surgery is still a matter of debate. The aim is to see if there is any correlation between increasing excision margin distance and local recurrence rate.
Debono, Joseph, Cassar, Noel, Torpiano, Paul   +2 more
core  

The Outcome of Patients with Melanoma Is Not Associated with the Time Point of Lymphatic Mapping with Respect to Excisional Biopsy of the Primary Tumor [PDF]

, 2010
Background: Sentinel lymph node biopsy (SLNB) has become the standard care for melanoma and is an important diagnostic procedure. It has been doubted whether lymphoscintigraphy detects the correct sentinel lymph node (SLN) when excision of the tumor and ...
Ruzicka, T., Berking, Carola, Geimer, Till, Geimer, T., Kunte, C., Berking, C., Baumert, Jens, Schmid-Wendtner, Monika-Hildegard, Gauwerky, Katharina J., Kunte, Christian, Flaig, Michael J., Gauwerky, K.J., Baumert, J.J., Flaig, M.J., Ruzicka, Thomas, Schmid-Wendtner, M.H.   +15 more
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Laparoscopic Bladder Diverticulum Excision in Boys: Three Case Reports

, 2023
Bladder diverticula can be congenital or acquired in children. In this study, we present three male patients with congenital bladder diverticulum who underwent laparoscopic diverticulum excision.
Zekeriya İlçe, Sevim Yener
core   +1 more source

Intersphincteric resection versus transanal local excision after neoadjuvant therapy for ultra-low rectal cancer: a two-center retrospective propensity-score-adjusted cohort study

Frontiers in Oncology
ObjectiveTo compare the long-term oncological outcomes and postoperative complications between local excision (LE) and intersphincteric resection (ISR) after neoadjuvant chemoradiotherapy (nCRT) in patients with ultra-low rectal cancer (ULRC).MethodsData
Guan-cong Wang, Guan-cong Wang, Jia-hong Ye, Yin-cong Guo, Ying Huang   +4 more
doaj   +1 more source

Localization and excision of occult breast lesions

Journal of British Surgery, 1983
Abstract Between 1976 and 1982, 190 non-palpable mammographic abnormalities considered to be suspicious of malignancy were excised using a needle localization technique. The indications for biopsy, technique for localization, method for confirmation of excision and histopathological preparation are presented.
U, Chetty, A E, Kirkpatrick, T L, Anderson, J, Lamb, M M, Roberts, V, Humeniuk, A P, Forrest   +6 more
openaire   +2 more sources