Results 81 to 90 of about 6,425,933 (304)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Excision of odontoma with local anesthesia in an 8-year-old girl: A case report

open access: yes
Objective: The most prevalent odontogenic tumors of the jaws are termed odontomas, and they are identified by their slow expansion and no aggressive behavior.
Indriasari, Lely   +4 more
core   +2 more sources

Risk factors for upper tract urothelial recurrence following local excision of bladder cancer

open access: yesCancer Medicine, 2018
The mechanism of upper tract recurrence after local excision of bladder cancer remains unknown. This study was designed to identify risk factors for upper tract urothelial recurrence following local tumor excision of bladder cancer.
Ning Lin   +9 more
doaj   +1 more source

Eccentric hyperbola: A new modified cutaneous scar re-excision on convex surfaces

open access: yesJournal of Dermatology and Dermatologic Surgery, 2018
“Re-excision of scar” is a common procedure following diagnostic or therapeutic excision of skin cancer cutaneous lesions. With the conventional techniques, skin tension on convex surfaces results in deformity and elongated scars.
Georgios Pafitanis   +3 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

Local excision of uveal melanoma technique - puzzles.

open access: yes, 1986
Local excision of uveal melanoma technique ...
a. Bianco   +2 more
core  

Local excision inadequate in the treatment of anal canal leiomyosarcoma

open access: yesThe Saudi Journal of Gastroenterology, 2010
Leiomyosarcoma of the anal canal is an uncommon neoplasm of the gastrointestinal tract. We report a 45-year-old lady with anal canal leiomyosarcoma. In view of its rarity, we report its presentation and management.
Kumar G, Chandra Sarath, Krishnan R
doaj  

Complete response after chemoradiotherapy for rectal cancer: what is the reasonable approach?

open access: yesInnovative Surgical Sciences, 2017
With the increasing use of preoperative treatment rather than upfront surgery, it has become evident that the response of rectal carcinoma to standard chemoradiotherapy (CRT) shows a great variety that includes histopathologiocally confirmed complete ...
Rödel Claus   +2 more
doaj   +1 more source

Endometriosis in an episiotomy scar

open access: yesÇukurova Üniversitesi Tıp Fakültesi Dergisi, 2016
Endometriosis that is defined as the presence of functional endometrial tissue outside the uterine cavity is seen 5-10% of reproductive age women. Endometriosis can be seen any other site of the body; but the most frequently affected areas are ovaries ...
Mine islimye Taskin   +3 more
doaj   +1 more source

Prospecting the protein design landscape

open access: yesFEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona   +4 more
wiley   +1 more source

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