Results 61 to 70 of about 216,031 (287)

Local terahertz field enhancement for time-resolved x-ray diffraction

, 2017
We report local field strength enhancement of single-cycle terahertz (THz) pulses in an ultrafast time-resolved x-ray diffraction experiment. We show that patterning the sample with gold microstructures increases the THz field without changing the THz
Hoffmann, M. C., M. Kozina, M. C. Hoffmann, P. Marsik, Driel, T. van, Bernhard, Christian, Pancaldi, M., M. Pancaldi, Bonetti, Stefani,, D. Zhu, M. Radovic, Kozina, M., Hoffmann, Matthias C., Glownia, J. M., C. A. F. Vaz, Vaz, C. A. F., Bonetti, S., Maršík, Premysl, Van Driel, T., Pancaldi, Matteo,, Pancaldi, Matteo, U. Staub, S. Bonetti, Vaz, Carlos A. F., Zhu, D., Bonetti, Stephano, Radovic, M., Staub, U., Bernhard, C., J. M. Glownia, Marsik, P., T. van Driel, C. Bernhard   +32 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Spectral Shape Control of Laser-Induced Terahertz Waves from Micro Split-Ring Resonators Made of Metallic Nanostructures

Photonics
Efficient terahertz sources with controllable characteristics such as frequency range and polarization state are being rapidly researched and developed to suit various practical applications. To address this need, we realized the idea of combining micro-
Thanh Nhat Khoa Phan, Kosaku Kato, Keisuke Takano, Shinsuke Fujioka, Makoto Nakajima   +4 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Large-area enhancement of far-field fluorescence intensity using planar nanostructures

APL Photonics, 2019
While nanoscale local enhancement of fluorescence is a well-studied phenomenon, enhancement of far-field radiation of large-area samples using nanostructures has been explored much less.
Markus Nyman, Andriy Shevchenko, Igor Shavrin, Yoichi Ando, Klas Lindfors, Matti Kaivola   +5 more
doaj   +1 more source

Local-field enhancement of spontaneous decay in nanosystems: some estimations for dielectric particles

, 2019
Enhancement of the spontaneous decay rate due to local-field effects is estimated for a luminous dipole inside a small dielectric particle. To do this, we make use of an idea on multiplicativity of the local-field factor. Elongated particles are shown to
Dvoynenko, MM, Goncharenko, AV, Lozovski, VZ, Kim, KS   +3 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Geometrical Dependent Local Filed Enhancement Factor and Optical Induced Bistability of ZnO@Ag Core-Shell Nanocomposite

Materials and Devices
In this study, the author investigated the local field enhancement factor and optically induced bistability (OIB) in spherical and cylindrical ZnO@Ag core–shell nanostructures embedded in a linear host matrix, considering the effects of the interfacial ...
Gashaw Kassahun
doaj   +6 more sources