Results 41 to 50 of about 20,684,051 (242)

Guidelines on parking management : sustainable mobility [PDF]

, 2023
This document is one in a series of documents on Sustainable Mobility and includes other important subjects – Walkability and Accessibility, Shared Transport, Last Mile Transportation and EV Changeover, previously issued by the Local Councils ...
Zammit, Antoine, Local Councils' Association   +1 more
core  

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Variability of seizure-like activity in an in vitro model of epilepsy depends on the electrical recording method

Heliyon, 2020
Background: Hippocampal and cortical slice-based models are widely used to study seizures and epilepsy. Seizure detection and quantification are essential components for studying mechanisms of epilepsy and assessing therapeutic interventions.
Shabnam Ghiasvand, Chris R. Dussourd, Jing Liu, Yu Song, Yevgeny Berdichevsky   +4 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Wireless Closed-Loop Optical Regulation System for Seizure Detection and Suppression In Vivo

Frontiers in Nanotechnology, 2022
There are approximately 50 million people with epilepsy worldwide, even about 25% of whom cannot be effectively controlled by drugs or surgical treatment. A wireless closed-loop system for epilepsy detection and suppression is proposed in this study. The
Yamin Li, Yamin Li, Shengwei Xu, Shengwei Xu, Yang Wang, Yang Wang, Yiming Duan, Yiming Duan, Qianli Jia, Qianli Jia, Jingyu Xie, Jingyu Xie, Xiaowei Yang, Yiding Wang, Yiding Wang, Yuchuan Dai, Yuchuan Dai, Gucheng Yang, Gucheng Yang, Miao Yuan, Miao Yuan, Xiaoting Wu, Xiaoting Wu, Yilin Song, Yilin Song, Mixia Wang, Mixia Wang, Hongda Chen, Hongda Chen, Yijun Wang, Yijun Wang, Xinxia Cai, Xinxia Cai, Weihua Pei, Weihua Pei, Weihua Pei   +35 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Multimodal Modeling of Neural Network Activity: Computing LFP, ECoG, EEG, and MEG Signals With LFPy 2.0

Frontiers in Neuroinformatics, 2018
Recordings of extracellular electrical, and later also magnetic, brain signals have been the dominant technique for measuring brain activity for decades.
Espen Hagen, Espen Hagen, Solveig Næss, Torbjørn V. Ness, Gaute T. Einevoll, Gaute T. Einevoll   +5 more
doaj   +1 more source