Results 61 to 70 of about 10,557,266 (383)
The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1
FEBS Letters, EarlyView.MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson +7 more
wiley +1 more source
Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation
FEBS Letters, EarlyView.The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen +2 more
wiley +1 more source
The 2011 Commonwealth Local Government Conference: Energising Local Economies: An Overview
Commonwealth Journal of Local Governance, 2011 In the current economic climate, creating the right environment for local enterprise, inward investment, and business and skills development, is an important factor in ensuring the prosperity and wellbeing of local communities.
Sue Rhodes
doaj +1 more source
Competition, Cooperation, and Local Government [PDF]
, 2006 Inspired by the best-selling "Reinventing Government", governments at all levels have decentralized programs and services and introduced market-based competition into operations.
Mildred Warner
core
Transparency of local government in Indonesia
Asian Journal of Accounting Research, 2018 Purpose The purpose of this paper is to provide empirical evidence about the influence of the size of local government, the quality of local government financial statements, the level of local government response to the disclosure of financial ...
I. Adiputra, S. Utama, Hilda Rossieta
semanticscholar +1 more source
FEBS Letters, EarlyView.In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker +8 more
wiley +1 more source
Commonwealth Journal of Local Governance, 2010 Editorial by Graham Sansom.
Graham Sansom
doaj +3 more sources
, 2019 After several years of reforms inspired by the New Public Management approach, public sector accounting and performance measurement systems continue to differ among countries.
Sandra Cohen +3 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile +8 more
wiley +1 more source
Local Government Website Updated Report Card [PDF]
, 2018 In 2017, the Buffalo Niagara Coalition for Open Government evaluated the websites of sixteen municipalities in Erie and Niagara ...
Buffalo Niagara Coalition for Open Government
core +1 more source