Results 61 to 70 of about 10,897,900 (408)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

A Decade of improvement for local government

open access: yesCommonwealth Journal of Local Governance, 2010
The theme of this year’s Commonwealth Local Government Conference was Improving local government: the Commonwealth vision. This theme is fundamental to all of us working in and with local government, but particularly so in the current economic climate ...
Susan Rhodes
doaj   +1 more source

Nigerian Federalism: The Quest for Restructuring

open access: yesJurnal Studi Pemerintahan, 2023
The quest for restructuring Nigeria’s federal system has been a frequent tune from most of her citizens. This challenge has created a wide gap in the federation which threatens the sovereignty of the nation. These agitations for secession/disintegration,
AYOTUNDE DAVID ODEWALE   +2 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

The Contribution of Family Businessesto Economic Growth: A Bibliometric Review

open access: yesSAGE Open
The aim of this study is to review the body of literature on the contribution of family businesses to economic growth. The Scopus database was used to conduct the bibliometric analysis of the topic under discussion.
Wakara Ibrahimu Nyabakora
doaj   +1 more source

Review of the Commonwealth Local Government Good Practice Scheme

open access: yesCommonwealth Journal of Local Governance, 2012
The overarching objective of the Commonwealth Local Government Good Practice Scheme (GPS) was to contribute towards the achievement of the Millennium Development Goals at the local level; there were four expected outputs: 1.
Rachael Duchnowski
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

open access: yesMolecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He   +8 more
wiley   +1 more source

The Local Capacity, Local Community and Local Governance Dimensions of Sustainability in Australian Local Government

open access: yesCommonwealth Journal of Local Governance, 1970
The problem of the ‘financial sustainability’ of individual local councils represents the most significant policy question at issue in contemporary debate on Australian local government. This concern with financial sustainability has not only dominated almost all recent local government conferences across Australia, but it has also formed the capstone ...
Dollery, Brian   +2 more
openaire   +5 more sources

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