Results 71 to 80 of about 579,379 (266)
Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Management & Social PerspectivesThis systematic review examines critical factors causing time and cost overruns in Sub-Saharan African construction projects. Analyzing 32 articles using the PRISMA approach, the study identifies seven key factors: financial, contractual/legal, project ...
Richard Gustave Kusongwa +2 more
doaj
Intégrer les jeunes à la démocratie locale en Grande-Bretagne : tensions au New Labour
Lien Social et Politiques, 2002 La faible participation politique des jeunes et leur désenchantement vis-à-vis du débat politique constituent une question centrale, non seulement en Grande-Bretagne mais dans l’ensemble de l’Europe et des pays industrialisés.
Mike Geddes
doaj +1 more source
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1
FEBS Open Bio, EarlyView.The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay +2 more
wiley +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
Commonwealth Journal of Local Governance, 2018 Local Government in England: Centralisation, Autonomy and Control is a serious book and an important contribution to the scholarship around local government. It opens however, with a pleasingly comic tableau as academics from England, Portugal and Poland
Jonathan Carr-West
doaj +1 more source
In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols
FEBS Open Bio, EarlyView.Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton +6 more
wiley +1 more source
Implementing the Aberdeen Agenda in South Asia: A regional training program for elected members
Commonwealth Journal of Local Governance, 2009 In 2005 CLGF members adopted the Aberdeen Agenda: Commonwealth Principles on Good Practice for Local Democracy and Good Governance. The twelve Principles were developed at the CLGF’s biennial conference in March 2005 and were subsequently forwarded to ...
Lucy Slack
doaj +1 more source