Results 51 to 60 of about 493,812 (272)

Yersinia pestis genomes reveal plague in Britain 4000 years ago

open access: yesNature Communications, 2023
Extinct lineages of Yersinia pestis, the causative agent of the plague, have been identified in several individuals from Eurasia between 5000 and 2500 years before present (BP). One of these, termed the ‘LNBA lineage’ (Late Neolithic and Bronze Age), has
Pooja Swali   +23 more
doaj   +1 more source

Localizing groups with action

open access: yesPublicacions Matemàtiques, 1989
When localizing the semidirect product of two groups, the effect on the factors is made explicit. As an application in Topology, we show that the loop space of a based connected CW-complex is a P-local group, up to homotopy, if and only if π1X and the free homotopy groups [S k-1, ΩX], k ≥ 2, are P-local.
openaire   +6 more sources

Localization for nonabelian group actions

open access: yesTopology, 1995
Suppose $X$ is a compact symplectic manifold acted on by a compact Lie group $K$ (which may be nonabelian) in a Hamiltonian fashion, with moment map $ : X \to {\rm Lie}(K)^*$ and Marsden-Weinstein reduction $\xred = ^{-1}(0)/K$. There is then a natural surjective map $ _0$ from the equivariant cohomology $H^*_K(X) $ of $X$ to the cohomology $H ...
Jeffrey, L, Kirwan, F
openaire   +3 more sources

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

open access: yesFEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma   +8 more
wiley   +1 more source

Healthcare Workers Training Courses on Vaccinations: A Flexible Format Easily Adaptable to Different Healthcare Settings

open access: yesVaccines, 2020
Since 2017, Italy has expanded the compulsory vaccination from 4 to 10 for those aged 0 to 16 years. Because of the great organizational effort required for the immunization services, minor attention was given to the vaccinations not included among the ...
Laura Serino   +7 more
doaj   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

open access: yesFEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto   +2 more
wiley   +1 more source

The Discontinuity Group of a Locally Bounded Homomorphism of a Lie Group into a Lie Group Is Commutative [PDF]

open access: yesarXiv, 2023
We prove that the discontinuity group of every locally bounded homomorphism of a Lie group into a Lie group is not only compact and connected, which is known, but is also commutative.
arxiv  

Localizations of Groups

open access: yes, 2000
A group homomorphism eta:A-> H is called a localization of A if every homomorphism phi:A-> H can be `extended uniquely' to a homomorphism Phi:H-> H in the sense that Phi eta = phi. This categorical concepts, obviously not depending on the notion of groups, extends classical localizations as known for rings and modules.
Göbel, Rüdiger, Shelah, Saharon
openaire   +2 more sources

Compact Groups: Local Groups?

open access: yesThe Astronomical Journal, 2000
It is concluded that faint members found in the vicinities of compact groups (CGs) are gravitationally bound with corresponding groups. All members of CGs, faint and bright, move preferentially in the direction of the elongation of the group. We suppose that the number of faint members may be much larger than previously assumed. These two circumstances
V. H. Chavushyan, Hrant M. Tovmassian
openaire   +2 more sources

Identification of novel small molecule inhibitors of ETS transcription factors

open access: yesFEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla   +9 more
wiley   +1 more source

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