Results 101 to 110 of about 14,031,347 (347)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Аkshoky burial ground: a new monument in the system of Andronovo antiquities of Saryarka

open access: yesВестник археологии, антропологии и этнографии, 2017
In recent years, archaeological studies have covered a group of Fedorovo monuments, which demonstrate a «pure» line of development (Besoba, Sherubai-1, Bada, etc.). A multigrave structure 1 excavated at the Akshoky burial is one of these complexes.
Kukushkin I.A.   +2 more
doaj   +1 more source

Split-Screen : Videogame History through Local Multiplayer Design [PDF]

open access: yes
By looking at videogame production through a two-vector model of design – a practice determined by the interplay between economic and technological evolution – we argue that shared screen play, as both collaboration and competition ...
Grabarczyk, Pawel   +1 more
core  

On the kinematic evolution of young local associations and the Sco-Cen complex

open access: yes, 2008
Context: Over the last decade, several groups of young (mainly low-mass) stars have been discovered in the solar neighbourhood (closer than ~100 pc), thanks to cross-correlation between X-ray, optical spectroscopy and kinematic data.
Fernandez, D., Figueras, F., Torra, J.
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

The National Fund for Workforce Solutions: A History of Collaborations [PDF]

open access: yes, 2008
Traces the history of cross-funder investment by local, national, private, and public funders in an initiative to strengthen and expand "workforce intermediaries" as a way to improve workforce training delivery through regional funding ...

core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

YARATKULOVO – A NEW H-CHONDRITE IN THE URALS: MINERALOGICAL DATA [PDF]

open access: yesМинералогия, 2017
The Yaratkulovo meteorite was found in 2016 in the Argayash district of the Chelyabinsk region. It is a «chondrite breccia», in which the light coarse-grained fragments (primary chondrite) occur in the dark fine-grained matrix (impact assemblages ...
V.V. Sharygin, S.V. Kolisnichenko
doaj  

Early Screening of the Autism Spectrum Disorders: Validity Properties and Cross-Cultural Generalizability of the First Year Inventory in Italy

open access: yesBrain Sciences, 2020
This study examined the cross-cultural generalisability of the First Year Inventory (FYI) on an Italian sample, testing its construct validity, consistency, and structural validity.
Annalisa Levante   +5 more
doaj   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

open access: yesMolecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts   +8 more
wiley   +1 more source

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