Results 111 to 120 of about 6,386,769 (253)

On the vanishing of (co)homology over local rings

open access: yes, 2008
Considering modules of finite complete intersection dimension over commutative Noetherian local rings, we prove (co)homology vanishing results in which we assume the vanishing of nonconsecutive (co)homology groups.
Bergh, Petter Andreas
core   +1 more source

MZF1 Inhibits TGFβ‐1/SMAD Signaling by Transcriptionally Activating SnoN to Augment Tumorigenic Potential in Colon Cancer

open access: yesAdvanced Science, EarlyView.
This study identifies MZF1 as a core regulator of colon cancer via SnoN‐mediated TGF‐β suppression, proposes 10Panx Acetate as a targeted inhibitor, and validates MZF1/SnoN as prognostic markers for aggressive disease. ABSTRACT Colon cancer progression is associated with transcriptional and signaling abnormalities.
Siqi Sheng   +9 more
wiley   +1 more source

Stratifying Multiparameter persistent homology (joint work with H. Harrington, N. Otter, U.Tillmann).

open access: yes, 2019
A fundamental tool in topological data analysis is persistent homology, which allows extraction of information from complex datasets in a robust way. Persistent homology assigns a module over a principal ideal domain to a one-parameter family of spaces ...
Schenck, Hal
core   +1 more source

Multiplexed CRISPR-Cas9 protocol for large transgene integration into the Schistosoma mansoni genome

open access: yesSTAR Protocols
Summary: Precise, on-target CRISPR-Cas9 genome editing has been shown in Schistosoma mansoni, involving both non-homology end joining and homology-directed repair pathways.
Wannaporn Ittiprasert   +3 more
doaj   +1 more source

homology-semanticsimilarity: homology_analysis

open access: yes, 2015
<p>Code, data, and results used for the homology manuscript.</p ...
Prashanti Manda
core   +1 more source

Targeting β2‐Adrenergic Receptor Stability With Lycorine Reveals a Host‐Directed Pathway for Antiviral Defense Against Poxviruses

open access: yesAdvanced Science, EarlyView.
Chronic stress drives autophagy‐mediated β2‐AR degradation, impairing antiviral immunity and promoting poxvirus lethality. Lycorine directly stabilizes β2‐AR to restore host defense, suppress excessive inflammation and improve survival. ABSTRACT Psychological stress is a pervasive yet poorly understood modulator of infectious disease outcomes. Here, we
Xin Zhang   +12 more
wiley   +1 more source

The Homology Cobordism Group

open access: yes, 2002
Let Σ0 and Σ1 be integral homology 3-spheres. They are said to be homology cobordant, or H-cobordant, if there exists a smooth compact oriented 4-manifold W with boundary ∂W= -Σ0 ∪ Σ1 such that the inclusions Σi → W induce isomorphisms H*(Σi, ℤ) → H*(W ...
Saveliev, Nikolai, Nikolai Saveliev
core   +1 more source

An Engineered HR1‐Stem Helix‐HR2 Trimeric Platform for Developing Broad‐Spectrum Coronavirus Vaccines

open access: yesAdvanced Science, EarlyView.
Sun et al. report a self‐assembling trimeric subunit vaccine platform termed RHS, which integrates the JN.1 receptor‐binding domain (RBD) with the heptad repeat 1 (HR1), stem helix (SH), and heptad repeat 2 (HR2) regions. The SARS‐CoV‐2 RHS vaccine elicits variant‐reactive RBD‐specific antibodies and cross‐reactive SH‐specific antibodies against ...
Xikui Sun   +18 more
wiley   +1 more source

Local and Analytic Cyclic Homology

open access: yes, 2007
Periodic cyclic homology is a homology theory for non-commutative algebras that plays a similar role in non-commutative geometry as de Rham cohomology for smooth manifolds. While it produces good results for algebras of smooth or polynomial functions, it
Meyer, Ralf, Ralf Meyer
core   +1 more source

Dual pKa Lipid Nanoparticles for Lung‐tropic mRNA Delivery and pH‐Programmed Endosomal Escape

open access: yesAdvanced Science, EarlyView.
Lipid nanoparticles’ bottleneck lies in low endosomal escape efficiency and liver‐dominant delivery after intravenous administration. To overcome these limitations, we present a stepwise pH‐programmed lipid nanoparticle system enabled by our newly synthesized ionizable lipid.
Seong Gi Lim   +12 more
wiley   +1 more source

Home - About - Disclaimer - Privacy