Results 91 to 100 of about 6,229,024 (291)

Localized delivery of therapeutic doxorubicin dose across the canine blood–brain barrier with hyperthermia and temperature sensitive liposomes

Drug Delivery, 2018
Most drugs cannot penetrate the blood–brain barrier (BBB), greatly limiting the use of anti-cancer agents for brain cancer therapy. Temperature sensitive liposomes (TSL) are nanoparticles that rapidly release the contained drug in response to ...
Amy Lee Bredlau, Anjan Motamarry, Chao Chen, M. A. McCrackin, Kris Helke, Kent E. Armeson, Katrina Bynum, Ann-Marie Broome, Dieter Haemmerich   +8 more
doaj   +1 more source

The potential for using combined electrical impedance and ultrasound measurements for the non-invasive determination of temperature in deep body tumours during mild hyperthermia [PDF]

The effectiveness of mild hyperthermia in improving the outcome of radiotherapy and chemotherapy treatment is well established for surface tumours (e.g.
Islam, Naimul
core  

Near‐Infrared Triggered Rechargeable Singlet Oxygen Battery for Sustained Phototherapy: Fast Charging and Long‐Lasting Discharging

Advanced Science, EarlyView.
A near‐infrared‐triggered rechargeable singlet oxygen battery based on PBDP nanoparticles is developed. Upon 808 nm irradiation for 5 min, the system enables efficient singlet oxygen generation, reversible storage via cycloaddition, and sustained release for up to 1 h after light cessation.
Yuxin Ren, Ling Li, Xinyi Zhang, Meiqi Li, Junqing Wang, Mengpan Zhang, Jian Wang, Yanli Tang   +7 more
wiley   +1 more source

Safety and efficacy of intravesical chemotherapy and hyperthermia in the bladder: results of a porcine study.

, 2022
Background Hyperthermia (heating to 43 °C) activates the innate immune system and improves bladder cancer chemosensitivity. Objective To evaluate the tissue penetration and safety of convective hyperthermia combined with intravesical mitomycin C (MMC ...
Longo, Thomas A, Maccarini, Paolo, Fantony, Joseph J, Inman, Brant A, Tan, Wei Phin, Grimberg, Dominic C, Spasojevic, Ivan, Brousell, Steven C, Chang, Andrew, Etienne, Wiguins   +9 more
core   +1 more source

Spatiotemporally Precise Rheumatoid Arthritis Therapy via a Triple‐Locked Cascaded Nanoplatform With Dual‐Channel Self‐Reporting

Advanced Science, EarlyView.
An orthogonally programmable nanotheranostic (MB@YW NPs) enables precision therapy for rheumatoid arthritis. A triple‐locked (pH, HOCl/ONOO−, light) independently drives the release of methotrexate and sulfasalazine. Trackable by dual‐channel fluorescence, this coordinated drug delivery remodels the inflammatory microenvironment to markedly suppress ...
Jihong Liu, Wendi Zhu, Shiyun Xu, Shichang Liu, Wenjun Tang, Xiaoyu Ma, Ting Yang, Haojian Yang, Hongtong Wang, Lu Cao, Lijie Tan, Qi Wang   +11 more
wiley   +1 more source

Polyproline: A Synthetic Polypeptide With Unique Properties

Angewandte Chemie, EarlyView.
Poly‐L‐proline is a unique polypeptide distinguished by its well‐defined secondary structures and unusual thermal behavior. This mini review highlights recent advances in the synthesis of poly‐L‐proline by N‐carboxyanhydride (NCA) polymerization, the formation of structurally defined architectures and nanostructures, and emerging strategies that ...
Rosanna Le Scouarnec, Josué M. Galindo, Colin Bonduelle, Andreas Heise   +3 more
wiley   +2 more sources

Hyperthermia: A Neoadjuvant Therapeutic Approach in Cancer Treatment [PDF]

, 2017
Hyperthermia refers to elevation tumor temperature from 39 up to 43 degree Celsius. Actually Therapeutic Hyperthermia has been used as an adjuvant treatment for cancer, since end of the 19th century after observations William Coley who found that tumor ...
Faghihi Moghadam, Fahimeh, Fahimeh Faghihi Moghadam, Mohsen Bakhshandeh, Hüseyin Sahinbas, Sahinbas, Hüseyin, Bakhshandeh, Mohsen   +5 more
core   +1 more source

Membrane‐Targeted Nanoparticles for Neuronal Photomodulation

Advanced Science, EarlyView.
Immobilizing gold nanoparticles on the neural interface using a bioorthogonal approach generates localized heat upon exposure to near‐infrared light, temporarily inhibiting primary neuronal activity without damaging the cells. This precise placement and retention of nanoparticles at the cell membrane expand the strategies for non‐invasive neural ...
Ane Escobar, Ana Sánchez‐Iglesias, Davide Bello, Miriam Feijoo Barriga, Alex M. Ascensión, Laura Rodríguez‐Gómez, David Otaegui‐Bichot, Francisco Javier Gil‐Bea, Monica Carril, Marek Grzelczak   +9 more
wiley   +1 more source

Photothermal Hyperthermia Suppresses Liver Tumor Growth Via Hippo Signaling Pathway-Dependent Inhibition of Cell Proliferation and Induction of Apoptosis

Biological Procedures Online
Hepatocellular carcinoma (HCC) ranks as the third most common malignant tumor globally. Although hyperthermia has shown promise as a non-invasive treatment for tumors, its specific mechanisms and impact on HCC remain underexplored.
Jian Li, Yuanhua Qin, Yingying Yang, Hang Chen, Mengjuan Li, Yadi Liu, Bingjie Liu, Jingli Shang, Yu Zhang, Tao Han, Yuhan Hu, Feng Ren   +11 more
doaj   +1 more source

Hyperthermia-driven aberrations of secreted microRNAs in breast cancer in vitro

, 2016
Purpose: Expression profile alterations of nine breast cancer (BC)-associated secreted microRNAs (miRs) were determined under microenvironmental alterations occurring in tumour progression, metastasis or specific oncological treatment modalities. Thereto,
Markus Jäger (2866577), Elmar Stickeler (2866562), Thalia Erbes (2866565), Lucas Willmann (2866583), Silvia Waldeck (2866574), Gerta Rücker (50492), Sebastian Mayer (2866568), Marc Hirschfeld (2866580), Bernd Kammerer (14827), Gerald Gitsch (2866571)   +9 more
core   +1 more source