Harnessing the abscopal effect: mechanistic insights and therapeutic strategies for systemic cancer immunotherapy [PDF]
Frontiers in ImmunologyThe abscopal effect, defined as the regression of non-irradiated tumors following localized radiotherapy (RT), represents one of the most intriguing manifestations of systemic antitumor immunity. Although traditionally considered a rare and unpredictable
Linxi Cao, Siqi Tong, Haihui Jiang
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Thoracic Cancer, 2021 Due to the emergence of immune checkpoint inhibitors, the abscopal effect has gained more attention. We report a case of extracranial abscopal effect after whole‐brain irradiation therapy due to brain metastasis.
Takeshi Isobe +2 more
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Abscopal Effect in Radiation Therapy: The Immune Mechanisms and Clinical Advances [PDF]
MedCommThe abscopal effect is a systemic antitumor response to localized radiotherapy (RT) that has emerged as a central focus in the era of immunotherapy. Clinical evidence demonstrates that local RT can induce regression of distant, nonirradiated metastases ...
Yihong Dong +5 more
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CV1-secreting sCAR-T cells potentiate the abscopal effect of microwave ablation in heterogeneous tumors [PDF]
Cell Reports MedicineSummary: Microwave ablation (MWA) triggers a weak systemic immune response that leads to the abscopal regression of distant metastases while killing local tumors, known as the abscopal effect.
Bihui Cao +13 more
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Targeted APC Activation in Cancer Immunotherapy to Enhance the Abscopal Effect
Frontiers in Immunology, 2019 In oncology, the “abscopal effect” refers to the therapeutic effect on a distant tumor resulting from the treatment of local tumor (e. g., ablation, injection, or radiation).
Taha Merghoub, Luis Felipe Campesato
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Defining the abscopal effect in non-small cell lung cancer in the era of immunotherapy and lung ablation treatment: a narrative review [PDF]
Frontiers in MedicineThe abscopal effect, first described in 1953, refers to the regression of distant, non-irradiated tumors following localized therapy. Historically considered rare, interest in this phenomenon has increased with the introduction of immunotherapy and local
Illaa Smesseim +6 more
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Physical parameters and biological factors affect the abscopal effect of combining radiotherapy with immunotherapy: an update on preclinical works [PDF]
Frontiers in Public HealthIn the process of radiotherapy for cancer patients, there is an extremely low probability phenomenon that the distal tumor/metastasis away from the irradiation field undergoes regression after localized radiation therapy, which is called the abscopal ...
Wangcai Ren +20 more
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Abscopal Effect following Stereotactic Radiation Therapy to the Brain and Spleen in Metastatic Endometrial Cancer: A Case Report [PDF]
Case Reports in OncologyIntroduction: The abscopal effect of radiation therapy is a rare phenomenon in which immune activation induces the regression of distant, nonirradiated tumors.
Yukiko Fukuda +13 more
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Case Report: Abscopal effect of radiotherapy in a patient with metastatic duodenal adenocarcinoma and resistance to chemoimmunotherapy [PDF]
Frontiers in ImmunologyBackgroundDuodenal adenocarcinoma is a rare gastrointestinal malignancy, with limited clinical treatment data and a poor prognosis, especially when metastatic.
Yongping Hao +5 more
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CD4+ T cells facilitate the RT-induced abscopal effect by promoting antigen cross-presentation to CD8+ T cells at unirradiated tumor sites [PDF]
Journal for ImmunoTherapy of CancerBackground The local effect of radiotherapy (RT) is enhanced by CD8+ T-cell responses elicited through dendritic cell (DC)-mediated cross-presentation of tumor antigens, facilitated by RT-induced damage-associated molecular patterns.
Simone Gaedicke +11 more
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