Results 11 to 20 of about 9,952,723 (204)

Abscopal effect-induced spontaneous regression of distant metastases in malignant mesenchymal tumor: a case report [PDF]

Frontiers in Oncology
The abscopal effect refers to an anti-tumor response that occurs in areas where radiotherapy (RT) has not been directly administered but is triggered by the immune system. We presented a case of an undifferentiated pleomorphic sarcoma with three relapses
Meltem Kirli Bolukbas, Cemile Ozdemir, Esengul Kocak Uzel   +2 more
doaj   +4 more sources

Abscopal effect in a patient with malignant pleural mesothelioma treated with palliative radiotherapy and pembrolizumab [PDF]

Clinical and Translational Radiation Oncology, 2021
The abscopal effect describes the ability of locally administered radiotherapy to induce systemic antitumor effects. Although mentioned for the first time in the 1950s, records of abscopal effects, considered to be immune-mediated, are scarce with ...
Wambaka Ange Mampuya, Hasna Bouchaab, Niklaus Schaefer, Remy Kinj, Stefano La Rosa, Igor Letovanec, Mahmut Ozsahin, Jean Bourhis, George Coukos, Solange Peters, Fernanda G. Herrera   +10 more
doaj   +2 more sources

Microwave ablation induces abscopal effect via enhanced systemic antitumor immunity in colorectal cancer [PDF]

Frontiers in Oncology, 2023
BackgroundThermal ablation is the primary procedure for the local treatment of lung metastases. It is known that radiotherapy and cryoablation can stimulate an abscopal effect, while the occurrence of abscopal effect induced by microwave ablation is less;
Lu Yu, Hairong Xie, Linping Wang, Min Cheng, Jie Liu, Jie Liu, Jiamei Xu, Zhigang Wei, Xin Ye, Qi Xie, Jing Liang   +10 more
doaj   +2 more sources

Pure abscopal effect in a patient with advanced uterine carcinosarcoma

Radiology Case Reports, 2023
The abscopal effect is a rare phenomenon, in which tumor shrinkage in the nonirradiated metastatic region is observed after radiotherapy. Certainly, this response is sometimes reported with the combined use of immune-checkpoint inhibitors, but a pure ...
Kazuhiro Okamoto, MD, Kotaro Yoshio, MD, PhD, Shinsuke Shirakawa, MD, Kyohei Irie, MD, Naoyuki Ida, MD, PhD, Hirofumi Matsuoka, MD, PhD, Junko Haraga, MD, PhD, Chikako Ogawa, MD, PhD, Keiichiro Nakamura, MD, PhD, Shoji Nagao, MD, PhD, Hisashi Masuyama, MD, PhD   +10 more
doaj   +2 more sources

Stromal barriers to the abscopal effect [PDF]

Cancer Cell
In this issue of Cancer Cell, Zhang et al. reveal that PAI-1-induced SFRP2high cancer-associated fibroblasts reduce the abscopal effect of radioimmunotherapy. Targeting PAI-1 or SFRP2 enhances T cell recruitment and prevents the formation of an immunosuppressive perivascular niche, improving radioimmunotherapy's abscopal effect.
Tian Tao, Tian, Affò, Silvia
openaire   +4 more sources

A Review of the Abscopal Effect in the Era of Immunotherapy

Cureus, 2022
The abscopal effect is a systemic immune response mediated by the effects of radiation on the immune system. This effect has been observed in a number of cancer types in addition to lung cancer, including but not limited to renal cell carcinoma, hepatocellular carcinoma, lymphoma, and melanoma. The combination of radiation therapy and immune checkpoint
Nabrinsky, Edward, Macklis, Jason, Bitran, Jacob   +2 more
openaire   +4 more sources

Moving towards the Future of Radio-Immunotherapy: Could We “Tailor” the Abscopal Effect on Head and Neck Cancer Patients?

Immuno, 2021
The abscopal effect (AbE) is defined as radiation-induced shrinkage of distant, non-treated, neoplastic lesions and it is considered the best clinical picture of the efficient immune stimulation by irradiation.
Marco De Felice, Mariagrazia Tammaro, Davide Leopardo, Giovanni Pietro Ianniello, Giacinto Turitto   +4 more
doaj   +2 more sources

Abscopal Effect: Propitious or Pernicious?

The Journal of Contemporary Dental Practice, 2017
How to cite this article Sarode SC, Maniyar N, Sarode GS, Patil S. Abscopal Effect: Propitious or Pernicious? J Contemp Dent Pract 2017;18(5):349-351.
openaire   +2 more sources

Abscopal effect in metastatic renal cell carcinoma

Acta Clinica Belgica, 2016
We report a case about a possible abscopal effect in a patient with metastatic renal cell carcinoma. Palliative conventional radiation of a metastatic lesion in the neck was performed and in the months after this treatment had been applied, clearance of the non-irradiated lung metastases and a subcutaneous nodule was observed.
Mieke, Van de Walle, Jan, Demol, Lorenzo, Staelens, Sylvie, Rottey   +3 more
openaire   +3 more sources

Abscopal effect of radiotherapy combined with immune checkpoint inhibitors

Journal of Hematology & Oncology, 2018
Radiotherapy (RT) is used routinely as a standard treatment for more than 50% of patients with malignant tumors. The abscopal effect induced by local RT, which is considered as a systemic anti-tumor immune response, reflects the regression of non ...
Yang Liu, Yinping Dong, Li Kong, Fang Shi, Hui Zhu, Jinming Yu   +5 more
doaj   +2 more sources