Results 41 to 50 of about 9,952,723 (204)

Adding liposomal doxorubicin enhances the abscopal effect induced by radiation/αPD1 therapy depending on tumor cell mitochondrial DNA and cGAS/STING

Journal for ImmunoTherapy of Cancer, 2023
Background Localized radiotherapy (RT) can cause a T cell-mediated abscopal effect on non-irradiated tumor lesions, especially in combination with immune checkpoint blockade.
Simone Gaedicke, Elke Firat, Gabriele Niedermann, Liqun Wang, Ren Luo, Kateryna Onyshchenko, Xi Rao, Meidan Wang, Beatrice Menz, Anca-Ligia Grosu   +9 more
doaj   +1 more source

On target methods to induce abscopal phenomenon for Off‐Target effects: From happenstance to happenings

Cancer Medicine, 2023
Although the “abscopal phenomenon” has been described several decades ago, this phenomenon lately has been obtaining momentous traction with the dawn of immune‐based therapies.
Blessie Elizabeth Nelson, Jacob J. Adashek, Steven H. Lin, Vivek Subbiah   +3 more
doaj   +1 more source

Abscopal Effects of Local Radiotherapy Are Dependent on Tumor Immunogenicity

Frontiers in Oncology, 2021
Although abscopal tumor regression remains a rare phenomenon, interest in exploiting how radiation stimulates the immune system to induce systemic abscopal response is increasing.
Jin-Zhi Lai, Jin-Zhi Lai, Yan-Yang Zhu, Ying Liu, Lin-Lin Zhou, Li Hu, Ling Chen, Qiu-Yu Zhang   +7 more
doaj   +1 more source

Radiotherapy combined with immunotherapy: the dawn of cancer treatment

Signal Transduction and Targeted Therapy, 2022
Radiotherapy (RT) is delivered for purposes of local control, but can also exert systemic effect on remote and non-irradiated tumor deposits, which is called abscopal effect.
Zengfu Zhang, Xu Liu, Dawei Chen, Jinming Yu   +3 more
doaj   +1 more source

Corrigendum to “Celastrol nanoemulsion induces immunogenicity and downregulates PD-L1 to boost abscopal effect in melanoma therapy” [Biomaterials 269 (2021) 120604] [PDF]

, 2021
Corrigendum to “Celastrol nanoemulsion induces immunogenicity and downregulates PD-L1 to boost abscopal effect in melanoma ...
Qiu, Nasha, Shen, Limei, Hu, Mengying, Zhou, Xuefei, Liu, Yun, Shen, Youqing, Chen, Yanzuo, Gao, Jianqing, Liu, Qi, Huang, Leaf   +9 more
core   +1 more source

True abscopal effect in a patient with metastatic non-small cell lung cancer [PDF]

, 2021
BACKGROUND Systemic response to local anticancer treatment is a phenomenon called 'abscopal effect'. The immune system is thought to play a pivotal role in its occurrence.
Curioni-Fontecedro, Alessandra, Vilinovszki, Oliver; https://orcid.org/, Andratschke, Nicolaus, Huellner, Martin, Alessandra Curioni-Fontecedro, Stephanie G. C. Kroeze, Oliver Vilinovszki, Kroeze, Stephanie G C, Martin Huellner, Nicolaus Andratschke   +9 more
core   +1 more source

An oldest‐old non‐small cell lung cancer patient with abscopal effect in a single lesion

Thoracic Cancer, 2022
The abscopal effect without concomitant immunotherapy is a rare event, including among cases of lung cancer. Furthermore, the occurrence of limited abscopal effect for only a single lesion in the metastatic organ consistent with the irradiated organ ...
Tadashi Sakaguchi, Kentaro Ito, Kentaro Fujiwara, Yoichi Nishii, Satoru Ochiai, Yoshihito Nomoto, Osamu Hataji   +6 more
doaj   +1 more source

The abscopal effect: a sense of DNA damage is in the air

Journal of Clinical Investigation, 2021
Tumor metastasis is a singularly important determinant of survival in most cancers. Historically, radiation therapy (RT) directed at a primary tumor mass was associated infrequently with remission of metastasis outside the field of irradiation. This away-from-target or "abscopal effect" received fringe attention because of its rarity.
Timothy P. Lippert, Roger A. Greenberg
openaire   +2 more sources

Supplementary Figure S1 from Necroptosis-dependent Immunogenicity of Cisplatin: Implications for Enhancing the Radiation-induced Abscopal Effect

, 2023
Potency of platinum derivatives to facilitate the RT-induced abscopal effect in the B16-CD133 melanoma model.
Gabriele Niedermann (15051663), Kateryna Onyshchenko (15051648), Liqun Wang (15051651), Simone Gaedicke (15051654), Elke Firat (15051660), Ren Luo (15014750), Anca-Ligia Grosu (15051657)   +6 more
core   +1 more source

Supplementary Figure S2 from Necroptosis-dependent Immunogenicity of Cisplatin: Implications for Enhancing the Radiation-induced Abscopal Effect

, 2023
Potency of platinum derivatives to facilitate the RT-induced abscopal effect in the C51 colon carcinoma model.
Gabriele Niedermann (15051663), Kateryna Onyshchenko (15051648), Liqun Wang (15051651), Simone Gaedicke (15051654), Elke Firat (15051660), Ren Luo (15014750), Anca-Ligia Grosu (15051657)   +6 more
core   +1 more source