Results 31 to 40 of about 9,952,723 (204)
Abscopal effect in the radio and immunotherapy [PDF]
Radiation Oncology Journal, 2021 This review is devoted to a rare in clinical practice, but promising phenomenon of regression distant non-irradiated metastases in combination therapy of cancer patients. R. H. Mole in 1953 suggested introducing the term “abscopal effect” to denote the effect of ionizing radiation “at a distance from the irradiated volume but within the same organism.”
Pevzner, Alina M. +3 more
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Radiation-induced abscopal effect and its enhancement by programmed cell death 1 blockade in the hepatocellular carcinoma: A murine model study [PDF]
Clinical and Molecular Hepatology, 2021 Background/Aims The abscopal effect, a rare phenomenon induced by radiation, can be reinforced by immunotherapy. Although radiation therapy and immunotherapy are increasingly being utilized for the treatment of hepatocellular carcinoma (HCC), whether ...
Gyu Sang Yoo +5 more
doaj +1 more source
Abscopal effect of focused ultrasound combined immunotherapy in animal solid tumor model: a systematic reviews and meta-analysis [PDF]
Frontiers in ImmunologyIntroductionThe abscopal effect, a systemic anti-tumor response triggered by localized treatment, has gained attention but remains poorly understood.
Chao Hu +9 more
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Electroporation and Immunotherapy—Unleashing the Abscopal Effect [PDF]
Cancers, 2022 The discovery of electroporation in 1968 has led to the development of electrochemotherapy (ECT) and irreversible electroporation (IRE). ECT and IRE have been established as treatments of cutaneous and subcutaneous tumors and locally advanced pancreatic cancer, respectively.
Tobias Freyberg Justesen +4 more
openaire +3 more sources
Stereotactic Body Radiotherapy Immunological Planning—A Review With a Proposed Theoretical Model
Frontiers in Oncology, 2022 In the stereotactic body radiotherapy (SBRT) and immunotherapy era, we are moving toward an “immunological radiation plan”, i.e., radiation scheduling with abscopal effect as a vital endpoint as well.
Kumara Swamy
doaj +1 more source
Cancer Innovation, 2023 Local therapy modalities such as radiation therapy, photodynamic therapy, photothermal therapy, and cryoablation have been used to treat localized tumors for decades.
Sadik Ali Mohammad +3 more
doaj +1 more source
The Abscopal Effect of Radiation Therapy
Future Oncology, 2021 Radiation therapy (RT) in some cases results in a systemic anticancer response known as the abscopal effect. Multiple hypotheses support the role of immune activation initiated by RT-induced DNA damage. Optimal radiation dose is necessary to promote the cGAS-STING pathway in response to radiation and initiate an IFN-1 signaling cascade that promotes ...
Daniel J Craig +7 more
openaire +2 more sources
The Abscopal Effect in the Era of Checkpoint Inhibitors [PDF]
International Journal of Molecular Sciences, 2021 Therapy targeting immune checkpoints represents an integral part of the treatment for patients suffering from advanced melanoma. However, the mechanisms of resistance are responsible for a lower therapeutic outcome than expected. Concerning melanoma, insufficient stimulation of the immune system by tumour neoantigens is a likely explanation.
Ondřej Kodet +8 more
openaire +2 more sources
Systemic benefit of radiation therapy via abscopal effect
Frontiers in Oncology, 2022 Evidence of a systemic response related to localized radiation therapy (RT) in cancer management is rare. However, enhancing the immune response via immunotherapy followed by localized RT has shown evidence of tumor shrinkage to non-irradiated metastatic
Daniel J. Craig +5 more
doaj +1 more source
Generating and grading the abscopal effect: proposal for comprehensive evaluation of combination immunoradiotherapy in mouse models [PDF]
, 2017 : Numerous published case reports and forthcoming clinical trials combine immunotherapy and radiotherapy with the goal of demonstrating an abscopal effect reaction.
Marco Durante +54 more
core +2 more sources