Abscopal Effect in Radiotherapy Treatment
The abscopal effect is a phenomenon that occurs during the treatment of a metastatic cancer when the localized treatment of the tumor causes not only a shrinkage of the aforementioned, but also a shrinkage of tumors outside the scope of the localized treatment plan .The RT treatment also induced healing of metastases distant from the radiotherapy ...
Virginia Cirolla, L. Frati
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Clinical and Translational Radiation Oncology, 2018 Background: In the last years, limited studies have described that radiotherapy could produce important distant responses in unirradiated sites, the so-called “abscopal effect”.
Rodolfo Chicas-Sett +3 more
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The abscopal effect: mechanism of occurrence and prospects of using it in therapy of metastatic cancer [PDF]
Сибирский онкологический журналThe abscopal effect in oncology has been known for 70 years, but until recently its clinical significance was rather low. The development of immune response checkpoint inhibitors has led to an active study of this phenomenon.
A. V. Khachaturyan, P. V. Bulychkin
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Augmenting interferon-β and anti-PD-L1 antibody bolsters non-ablative radiotherapy to leverage potent abscopal effect in metastatic cancers [PDF]
Frontiers in ImmunologyBackgroundThe abscopal effect is a systemic anti-tumor immune response induced by local radiotherapy (RT), resulting in regression of distant, non-irradiated tumors.
Jin Hee Park +11 more
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Toward prediction of abscopal effect in radioimmunotherapy: Pre-clinical investigation.
PLoS ONE, 2021 PurposeImmunotherapy (IT) and radiotherapy (RT) can act synergistically, enhancing antitumor response beyond what either treatment can achieve separately. Anecdotal reports suggest that these results are in part due to the induction of an abscopal effect
Ivaylo B Mihaylov +5 more
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A Comprehensive Revision of Radiation Immunotherapy and the Abscopal Effect in Central Nervous System Metastases: Reassessing the Frontier [PDF]
Current Issues in Molecular BiologySeventy years ago, Robin Mole introduced the concept of the abscopal effect to describe a rare phenomenon. This occurs when local radiation triggers an immune-mediated reduction in tumors outside the treated area but within the same organism.
Júlia Moscardini-Martelli +13 more
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Abscopal effect: from a rare phenomenon to a new frontier in cancer therapy [PDF]
Biomarker ResearchRadiotherapy (RT) controls local lesions, meantime it has the capability to induce systemic response to inhibit distant, metastatic, non-radiated tumors, which is referred to as the “abscopal effect”.
Xueying Wang +3 more
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LiversThe liver is a common site for metastatic disease. In select patients with isolated liver metastases, surgical resection improves survival and may be potentially curative in patients with favorable “tumor biology”. However, when surgical resection is not
Jonah M. Levine +8 more
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Tumor-draining lymph node is important for a robust abscopal effect stimulated by radiotherapy
Journal for ImmunoTherapy of Cancer, 2020 Background Radiotherapy (RT) has been shown to stimulate an antitumor immune response in irradiated tumors as well as unirradiated distant sites (abscopal effect).
David Lawson +9 more
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Planned Abscopal Effect with Concurrent Pembrolizumab and Ablative Radiotherapy to Pulmonary Metastasis: A Case Report and Review of the Literature [PDF]
Current OncologyMost abscopal effects are reported as sporadic and unpredictable events following radiotherapy at symptomatic sites. Herein, we report a case in which a planned abscopal effect was induced following deliberate radiotherapy and concurrent systemic ...
Yu-Ting Lee +4 more
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