Results 91 to 100 of about 4,158,166 (297)
An Effective Optimization Method for Machine Learning Based on ADAM
Applied Sciences, 2020 A machine is taught by finding the minimum value of the cost function which is induced by learning data. Unfortunately, as the amount of learning increases, the non-liner activation function in the artificial neural network (ANN), the complexity of the ...
Dokkyun Yi, Jaehyun Ahn, Sangmin Ji
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Identifying and attacking the saddle point problem in high-dimensional non-convex optimization [PDF]
, 2014 A central challenge to many fields of science and engineering involves minimizing non-convex error functions over continuous, high dimensional spaces.
Caglar Gulcehre +6 more
core
On the Number of Errors Correctable with Codes on Graphs
, 2011 We study ensembles of codes on graphs (generalized low-density parity-check, or LDPC codes) constructed from random graphs and fixed local constrained codes, and their extension to codes on hypergraphs.
Barg, Alexander, Mazumdar, Arya
core +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Radiation Oncology, 2012 Background The purpose of this study is to investigate the prognostic factors of stereotactic radiotherapy for stage I NSCLC to improve outcomes. Methods Stage I non-small cell lung cancer patients who were treated with stereotactic radiotherapy between ...
Shirata Yuko +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
The Local Minimum Dataset of Biochemistry Laboratory Information Systems
مدیریت اطلاعات سلامت, 2016 Introduction: Biochemistry laboratories provide important information about the health status of people for clinical interventions and decisions. The purpose of this study was to evaluate the data elements of biochemistry laboratory information systems ...
Mehrnoosh Shahmoradi +2 more
doaj
Recovery of compartment model parameters of dynamical systems for the epidemiological SIR model [PDF]
Известия Саратовского университета. Новая серия: ФизикаBackground and Objectives: In problems where the model of dynamical system is known and the parameters need to be determined, researchers most often encounter the problem of ”getting stuck” in local minima of the cost function.
Korobko, Mikhail A. +1 more
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The Impact of Recent State and Local Minimum Wage Increases on Nursing Facility Employment. [PDF]
J Labor Res, 2022 McHenry P, Mellor JM.
europepmc +1 more source