Results 51 to 60 of about 5,442,599 (254)

Optical Identification of Cepheids in 19 Host Galaxies of Type Ia Supernovae and NGC 4258 with the Hubble Space Telescope [PDF]

, 2016
We present results of an optical search for Cepheid variable stars using the Hubble Space Telescope (HST) in 19 hosts of Type Ia supernovae (SNe Ia) and the maser-host galaxy NGC 4258, conducted as part of the SH0ES project (Supernovae and H0 for the ...
Amanullah, Rahman, Casertano, Stefano, Chornock, Ryan, Filippenko, Alexei V., Foley, Ryan J., Goobar, Ariel, Hoffmann, Samantha L., Macri, Lucas M., Riess, Adam G., Silverman, Jeffrey M., Tucker, Brad E., Welch, Douglas L., Yuan, Wenlong   +12 more
core   +3 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Time-Dependent Superfluid Local Density Approximation

, 2013
The time-dependent superfluid local density approximation (TDSLDA) is an extension of the Hohenberg-Kohn density functional theory (DFT) to time-dependent phenomena in superfluid fermionic systems.
Bulgac, Aurel, Forbes, Michael McNeil
core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Presse régionale et multisupports

Tic & Société, 2012
This article retraces the path followed  by a regional daily in France in diversifying its activities and enlisting its workers in the task of mastering a multichannel journalism.
Denis RUELLAN, Joël LANGONNE
doaj   +1 more source

Sliding Objects with Random Friction

, 1999
We study the motion of elastic networks driven over a random substrate. Our model which includes local friction forces leads to complex dynamical behavior. We find a transition to a sliding state which belongs to a new universality class.
Bak, Balents, Burridge, Cule, De Los Rios, Fiegelman, Fisher, Fisher, Fisher, Fukuyama, Giamarchi, Giamarchi, Hwa, Itzhak Webman, José Luis Gruver, Krug, Lee, Myers, Narayan, Narayan, Narayan, Parisi, Parisi, Pla, Shlomo Havlin, Villete, Webman   +26 more
core   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Smallholder oil palm value chain in Cameroon: A case study from the department of Sanaga-Maritime [PDF]

, 2014
Cameroon has been producing palm oil for centuries but industrial scale production started around 1907 under the German colonisation with the development of estates and mills around the Littoral region (Sanaga-Maritime).
Abdelhakim, Tahani, Aboubakar Hayatou, Iyabano, Feintrenie, Laurène, Miaro, Ludovic   +3 more
core  

Formalism for the Subhalo Mass Function in the Tidal-limit Approximation

, 2003
We present a theoretical formalism by which the global and the local mass functions of dark matter substructures (dark subhalos) can be analytically estimated.
Jounghun Lee, Peacock J. A.
core   +3 more sources