Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
What are the strategies and steps to build-up a dairy system in a harsh environment? The case of smallholder dairy farmers of Unaí - Brazil. [PDF]
, 2012 In the district of Unaí (Minas Gerais, Brazil), smallholder farmers face numerous challenges such as restricted access to land, capital and labor, weak collective organization and climatic constraints.
Cialdella, Nathalie +3 more
core
The selective phosphodiesterase 4 inhibitor roflumilast and phosphodiesterase 3/4 inhibitor pumafentrine reduce clinical score and TNF expression in experimental colitis in mice. [PDF]
, 2013 The specific inhibition of phosphodiesterase (PDE)4 and dual inhibition of PDE3 and PDE4 has been shown to decrease inflammation by suppression of pro-inflammatory cytokine synthesis.
A Hatzelmann +43 more
core +4 more sources
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Case Studies in Construction MaterialsThis study investigates 1000-hour and million-hour creep behaviors in load transfer components (LTCs) and evaluates the impact of LTC’s compression creep on fiber-reinforced polymer (FRP) cable extrusion-anchorage relaxation.
Jingyang Zhou +6 more
doaj +1 more source
Local biomass feedstocks availability for fueling ethanol production [PDF]
Crop Production/Industries, Resource /Energy Economics and Policy,
Shane, Richard +2 more
core +1 more source
Business strategies of companies and local production systems in Bulgarian dairy industry [PDF]
, 2015 Rozdział z: Functioning of the Local Production Systems in Central and Eastern European Countries and Siberia. Case Studies and Comparative Studies, ed. Mariusz E.
Radev, Radko
core
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Unpacking neoliberal policies: Interrupting the global and local production of the norms
, 2012 Unpacking neoliberal policies: Interrupting the global and local production of the norms Early Childhood Education and Care (ECEC) has been constructed as a new site for educational, sociocultural, political, and economic investment.
I-Fang Lee
semanticscholar +1 more source