Results 261 to 270 of about 909,585 (312)

RNA-binding protein IMP1/ZBP1 directs local translation in microglial processes to regulate motility and phagocytosis during inflammation. [PDF]

PLoS Biol
Imaz-Iruretagoyena J, Blanco-Urrejola M, Núñez-García I, García-Toledo I, Fernández-Beltrán LC, Márquez M, Corrochano S, Sierra A, Baleriola J.   +8 more
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A Duality of Function: An Integrative Model of RACK1 as a Switch Between Translational and Signaling Hubs. [PDF]

Int J Mol Sci
Kolosov P, Biziaev N, Alkalaeva E.
europepmc   +1 more source

Localized mRNAs and protein synthesis in cortical layer 1

Spanò T, Nassim-Assir B, Kaulich E, Tushev G, Fürst N, Will H, Marić L, Ciirdaeva E, Schuman EM.   +8 more
europepmc   +1 more source

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Local control of localized protein synthesis

Science, 2018
Cell Biology Localized protein synthesis provides spatiotemporal precision for injury responses and growth decisions at remote positions in nerve axons. Terenzio et al. show that this process is controlled by local translation of preexisting axonal mRNA encoding the master regulator mTOR (see the Perspective by Riccio).
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Local Protein Synthesis in Magnocellular Dendrites

1998
There is increasing evidence that an important aspect of gene expression in neurons involves local synthesis of proteins in their dendrites. Dendrites contain: (a) the relevant protein synthetic organelles—polyribosomes, rough endoplasmic reticulum (RER) and small elements of Golgi apparatus (1); (b) translational elements—rRNA, tRNA and translational ...
Dan Ma, John F. Morris
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Local protein synthesis, actin dynamics, and LTP consolidation

Current Opinion in Neurobiology, 2008
Modulation of local protein synthesis in neuronal dendrites plays a key role in the production of long-term, activity-dependent changes in synapse structure and functional efficacy. Such long-term changes also require regulation of actin dynamics in dendritic spines.
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Dendritic ribosomes suggest local protein synthesis during estrous synaptogenesis

NeuroReport, 2003
Synapse number and dendritic spine number fluctuate across the estrous cycle in the hippocampal CA1 stratum radiatum. The synaptogenesis phase of estrous is driven by estrogen and may require newly synthesized proteins. Ribosomes synthesize soluble proteins when free in the cytoplasm, and integral membrane or secretory proteins when membrane-associated.
J Brian, McCarthy, Teresa A, Milner
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Synapse Formation and Plasticity: The Roles of Local Protein Synthesis

The Neuroscientist, 2005
From simple reflexes in lower animals to complex motor patterns and learning and memory in higher animals, all nervous system functions hinge upon fundamental, albeit specialized, neuronal units termed synapses. The term synapse denotes the structural and functional building block upon which pivots the enormous information-processing capabilities of ...
Wiersma-Meems, R., van Minnen, J., Syed, N.I.   +2 more
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Local Synthesis of Axonal Protein

1984
Given that the axon is an extended cellular process remote from the neuron’s metabolic center, the supply of newly synthesized proteins to the axon is a question of fundamental importance. It is well established that one mode by which this is accomplished is by synthesis of axonal proteins in the cell body, whereupon products reach the axon by ...
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