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Local protein synthesis and its role in synapse-specific plasticity
Current Opinion in Neurobiology, 2000Long-lasting forms of learning-related synaptic plasticity require transcription and yet occur in a synapse-specific manner, indicating that there are mechanisms to target the products of gene expression to some but not other synapses of a given cell. Studies in a variety of systems have indicated that mRNA localization and synaptically regulated local
K C, Martin, M, Barad, E R, Kandel
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Local protein synthesis during axon guidance and synaptic plasticity
Current Opinion in Neurobiology, 2004mRNA localization and regulated translation take central roles in axon guidance and synaptic plasticity. By spatially restricting gene expression within neurons, local protein synthesis provides growth cones and synapses with the capacity to autonomously regulate their structure and function.
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Immunofluorescent localization of protein synthesis components in mouse embryo fibroblasts
Cell Biology International Reports, 1987The distribution of initiation factor 2(eIF-2) and elongation factor 2(EF-2) in cultured mouse embryo fibroblasts was studied and compared with the distribution of ribosomes. We used immunofluorescence microscopy with monospecific antibodies to eIF-2, EF-2, and proteins S3a and S7 of the small ribosomal subunit.
L P, Gavrilova +6 more
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Local Protein Synthesis in Invertebrate Axons: From Dogma to Dilemma
2001In the past decade, it has become increasingly apparent that both axonal and dendritic domains of neurons have a natural propensity to synthesize proteins locally, i.e., independently of their cell bodies. A combined cell biological, molecular and neurobiological approach has now provided unequivocal evidence which serves to demonstrate not only the ...
van Minnen, J., Syed, N.I.
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Sites of Localization and Synthesis of Ss Protein in Mice
The Journal of Immunology, 1974Abstract Ss, a serum protein whose structure and level in serum are determined by genes of the mouse H-2 complex, has been localized to a variety of cell types, using immunofluorescence and radiolabel techniques. Peritoneal macrophages and liver parenchymal cells appear to synthesize Ss for export to serum.
Saunders, D, Edidin, M
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Immunofluorescence localization of plasma protein synthesis in cultured chick hepatocytes
Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1979Fibrinogen, albumin and the major apoprotein of high density lipoprotein (apoprotein A) were localized in a primary embryonic chick liver cell culture by indirect immunofluorescence staining. Changes in the pattern of plasma protein synthesis under a variety of conditions, as measured by the accumulation of secreted plasma proteins in the culture ...
R G, Kalb, G, Grieninger
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Translating regeneration: Local protein synthesis in the neuronal injury response
Neuroscience Research, 2019Neurons convey signals over long distances, for example motor neurons and sensory neurons project axons up to a meter long in humans. To this end, a sophisticated network of long-range signaling mechanisms enables communication between neuronal processes and somata.
Sandip Koley +3 more
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Synthesis and localization of myeloperoxidase protein in transfected BHK cells
Experimental Cell Research, 1989Processing and localization of myeloperoxidase was studied in nonmyeloid cells. For this purpose BHK cells were transfected with human myeloperoxidase cDNA. In the transfected cells a protein with mol wt of 85,000 was found, which reacted with the specific anti-human myeloperoxidase antiserum.
J, Cully +6 more
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Regulation and function of local protein synthesis in neuronal dendrites
Trends in Biochemical Sciences, 2002It has long been shown that protein synthesis can occur in neuronal dendrites, but its significance remained unclear until relatively recently. Studies suggest that local protein synthesis has crucial roles in synaptic plasticity, the change in neuronal communication efficiency that is probably a cellular basis of learning and memory.
Jiang, C., Schuman, E.
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RNA Transport and Local Protein Synthesis in the Dendritic Compartment
2001The shape and composition of the postsynaptic membrane depend on synaptic activity and change throughout the lifetime of the synapse (for references, see Albright et al. 2000). The mechanisms underlying the establishment of the receptor mosaic at the postsynaptic membrane (synthesis, processing, targeting and insertion of receptors) are still poorly ...
Gardiol A, Racca C, Triller A
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