Results 51 to 60 of about 6,830,648 (263)
Metastasis-free survival after local recurrence of soft-tissue sarcoma
, 1993 We analysed metastasis-free survival after local recurrence in a population-based series of 432 patients treated for soft-tissue sarcoma of the extremities or trunk wall.
A Rydholm, KE Dreinhofer, P Gustafson
core +1 more source
Frontiers in Microbiology, 2022 Local recurrence and distant metastasis are the main causes of death in patients with pancreatic adenocarcinoma (PDAC). Microbial content in PDAC metastasis is still not well-characterized. Here, the tissue microbiome was comprehensively compared between
Shenming Li +5 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Salvage treatment for local recurrence
, 2014 Summary Local recurrence of nasopharyngeal carcinoma is potentially salvageable by surgery or radiotherapy. In this chapter, the different salvage treatments for local recurrence including brachytherapy, external radiation using stereotactic and ...
Dora LW Kwong +3 more
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Frontiers in OncologySynopsisThis is a systematic review and meta-analysis comparing surgical excision with percutaneous ultrasound-guided vacuum-assisted excision (US-VAE) for the treatment of benign phyllodes tumor (PT) using local recurrence (LR) as the endpoint ...
Maria Luísa Braga Vieira Gil +25 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Local recurrence after enlarged total nephrectomy
, 2019 Local isolated recurrence of kidney cancer in the renal lodge after radical nephrectomy is rare and has a poor prognosis. Surgical excision, sometimes even extended to neighboring organs, is currently the only effective treatment for local recurrence of ...
Messian Gallouo +5 more
core +1 more source
Frontiers in OncologyStudy objectivePhyllodes tumors of the breast (PT) are rare fibroepithelial tumors with varied clinical and histopathological characteristics, and standardized with wide margins in surgery, a systemic retrospective study of PT could improve our ...
Ye Han +4 more
doaj +1 more source
Frontiers in Oncology, 2019 Purpose: To retrospectively assess clinical outcomes and toxicity profile of prostate cancer patients treated with delayed dose-escalated image-guided salvage radiotherapy (SRT) for macroscopic local recurrence after radical prostatectomy (RP).Material ...
Mohamed Shelan +7 more
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source