Results 71 to 80 of about 6,553,326 (307)

Pediatric Mediastinal Gray Zone Lymphoma With Germline TET2 Heterozygous Variant

Pediatric Blood &Cancer, EarlyView.
Matthew R. Schuelke, Julia Wang, Haley Newman, Evelyn Kurpiewski, Anne Reilly, Susan R. Rheingold, Gerald Wertheim, Moe Takeda, Daniel J. Zheng, Kaitlin Devine   +9 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Intensity-modulated radiation therapy for T4 nasopharyngeal carcinoma Treatment results and locoregional recurrence

, 2017
The purpose of this work was to examine outcomes in patients with T4 nasopharyngeal carcinoma (NPC) treated with intensity-modulated radiation therapy (IMRT).
陳雅芳;陳婉瑜;郭頌鑫;洪瑞隆;蔡巧琳;王駿瑋;黃昱森;婁培人, Chen, J. L. -Y.;Huang, Y. -S.;Kuo, S-H.;Chen, Y. -F.;Hong, R. -L.;Ko, J. -Y.;Lou, P. -J.;Tsai, C. -L.;Chen, W. -Y.;Wang, C. -W.   +1 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Fast neutron therapy in Tomsk: 40-year experience in cancer treatmnet

Сибирский онкологический журнал
The purpose of the study was to evaluate the efficacy of neutron therapy (NT) for salivary gland cancer and recurrent breast cancer. Material and Methods.
Zh. A. Startseva, O. V. Gribova, V. V. Velikaya, E. S. Sukhikh, V. A. Lisin, V. A. Novikov   +5 more
doaj   +1 more source

Preoperative Stereotactic Radiosurgery for Brain Metastases

Frontiers in Neurology, 2018
Stereotactic radiosurgery (SRS) is increasingly utilized to treat the resection cavity following resection of brain metastases and recent randomized trials have confirmed postoperative SRS as a standard of care.
David M. Routman, Elizabeth Yan, Sujay Vora, Jennifer Peterson, Jennifer Peterson, Anita Mahajan, Kaisorn L. Chaichana, Nadia Laack, Paul D. Brown, Ian F. Parney, Terry C. Burns, Daniel M. Trifiletti, Daniel M. Trifiletti   +12 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Oncologic Impact of Conservative Treatment Compared with Surgical Treatment of Anastomotic Leakage Following Colorectal Cancer Surgery: A Retrospective Study

Journal of the Anus, Rectum and Colon
Objectives: Differences in oncological outcomes between conservative and surgical treatments for anastomotic leakage (AL) in patients undergoing colorectal cancer surgery remain unclear.
Junichi Sakamoto, Atsuko Tsutsui, Chie Hagiwara, Go Wakabayashi   +3 more
doaj   +1 more source

Alginate Oligosaccharide DP5 Exhibits Antitumor Effects in Osteosarcoma Patients following Surgery

Frontiers in Pharmacology, 2017
Osteosarcoma is a malignant musculoskeletal tumor that has high-rate morbidity and mortality worldwide. Alginate oligosaccharide (AOS), a natural product, has antitumor activities and may have therapeutic effects in osteosarcoma, the molecular mechanisms
Jiayu Chen, Yu Hu, Lirong Zhang, Yingjian Wang, Shichao Wang, Yanzi Zhang, Haiyan Guo, Degang Ji, Yingtao Wang   +8 more
doaj   +1 more source

Recurrence quantification analysis of global stock markets [PDF]

This study investigates the presence of deterministic dependencies in international stock markets using recurrence plots and recurrence quantification analysis (RQA). The results are based on a large set of free float-adjusted market capitalization stock
Joao A. Bastos, Jorge Caiado
core