Results 71 to 80 of about 6,830,648 (263)

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Intensity-modulated radiation therapy for T4 nasopharyngeal carcinoma Treatment results and locoregional recurrence

, 2017
The purpose of this work was to examine outcomes in patients with T4 nasopharyngeal carcinoma (NPC) treated with intensity-modulated radiation therapy (IMRT).
陳雅芳;陳婉瑜;郭頌鑫;洪瑞隆;蔡巧琳;王駿瑋;黃昱森;婁培人, Chen, J. L. -Y.;Huang, Y. -S.;Kuo, S-H.;Chen, Y. -F.;Hong, R. -L.;Ko, J. -Y.;Lou, P. -J.;Tsai, C. -L.;Chen, W. -Y.;Wang, C. -W.   +1 more
core   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Local recurrence after breast-conserving surgery for breast cancer

, 1996
Local recurrence following breast-conserving surgery for breast cancer is a significant failure of local treatment. This article reviews the mechanisms, risk factors and overall significance of such local recurrence.
Macmillan, R D, Purushotham, A D; id_orcid, George, W D   +2 more
core   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Details of patients with local recurrence.

, 2015
Abbreviations: CEA, serum carcinoembryonic antigen; RFS, relapse free survival.Details of patients with local recurrence.
Lan Xie (686991), Xin An (223076), Qiao-Xuan Wang (686990), Pei-Qiang Cai (514154), Xu Zhang (49484), Pei-Rong Ding (223066), Shao-Hua Li (345353), Zhi-Zhong Pan (457626)   +7 more
core   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Effect of bisphosphonates on local recurrence of giant cell tumor of bone: a meta-analysis

, 2019
Mingmin Shi,1 Lei Chen,2 Yangxin Wang,1 Wei Wang,1 Yujie Zhang,1 Shigui Yan1 1Department of Orthopaedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China; 2Department of ...
Shi M, Zhang Y, Chen L, Wang W, Yan S, Wang Y   +5 more
core  

Clinical factors and time of local recurrence.

, 2013
A.-E. Kaplan-Meier curves for local recurrence-free survival after BCT, stratified by age (A), surgical margin status (B), node-positivity (C), ER status (D) and PgR status (E).
Haruka Handa (343721), Hiroki Shirato (443430), Jin-Min Nam (467487), Shigeru Hashimoto (209645), Rumiko Kinoshita (467486), Shunsuke Onodera (467491), Shinya Tanaka (148975), Yoichi M. Ito (352462), Yutaro Otsuka (343719), Yasuhito Onodera (467489), Kanako C. Hatanaka (467488), Ari Hashimoto (209637), Shinichi Shimizu (467492), Mitsuchika Hosoda (467490), Hisataka Sabe (209680), Mishie Tanino (148967)   +15 more
core   +1 more source