Results 81 to 90 of about 6,553,326 (307)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

A novel approach for local treatment of breast cancer [PDF]

, 2002
Early local recurrence of breast cancer most commonly (over 90%) occurs at the site of the primary tumour. This is true whether or not radiotherapy is given and irrespective of the margin status. Whole-organ analysis of mastectomy specimens on the other
Vaidya, J.S.
core  

Surveillance mammography for detecting ipsilateral breast tumour recurrence and metachronous contralateral breast cancer : a systematic review [PDF]

, 2011
Peer ...
Heys, Steve D, Ruth E Thomas, Ragupathy, Senthil Kumar Arcot, Boachie, Charles, Fraser, Cynthia, Graeme MacLennan, Robertson, Clare, Steve D Heys, Mammographic Surveillance Health Technology Assessment Group, Pinder, Sarah; id_orcid, Graham Mowatt, ?, ?, Charles Boachie, null null, Clare Robertson, Maclennan, Graeme, Thomas, Ruth E, Gilbert, Fiona J, Senthil Kumar Arcot Ragupathy, Fiona J Gilbert, Mowatt, Graham, Cynthia Fraser   +21 more
core   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Recent advances in neoadjuvant chemoradiotherapy in locally advanced rectal cancer

Journal of the Anus, Rectum and Colon, 2017
Preoperative chemoradiotherapy (CRT) has been actively used in Europe and the United States to treat advanced low rectal cancer, and provides excellent local control. In Japan, however, the standard treatment is lateral lymph node dissection, and to date
Kazushige Kawai, Soichiro Ishihara, Hiroaki Nozawa, Keisuke Hata, Tomomichi Kiyomatsu, Toshiaki Tanaka, Takeshi Nishikawa, Kensuke Otani, Koji Yasuda, Koji Murono, Kazuhito Sasaki, Toshiaki Watanabe   +11 more
doaj   +1 more source

Radiation Therapy for Local or Biochemical Recurrence Following Radical Prostatectomy in Patients with Prostate Cancer [PDF]

Hiroki Nishiyama,1,* Gen Kawaguchi,2,* Kozue Ito,3 Go Hasegawa,3 Yohei Ikeda,4 Noboru Hara,1 Tsutomu Nishiyama1 1Department of Urology, Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, Minamiuonuma ...
Nishiyama T, Hasegawa G, Ikeda Y, Ito K, Nishiyama H, Kawaguchi G, Hara N   +6 more
core  

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

LOCAL RECURRENCE OF RECTAL CANCER [PDF]

, 1989
One hundred twenty-six rectal cancers were operated upon in the First Department of Surgery, Nagasaki University School of Medicine. Local recurrence occurred in thirty-three (26.2%).
Miura, Toshio, Honjo, Seiji, Hisano, Hiroshi, Tomita, Masao, Okada, Daikichi, Yamaguchi, Hiroyuki, Shimoyama, Takatoshi, Nakazaki, Takayuki   +7 more
core   +3 more sources

Recurrence-free survival stratified by size of HCC.

, 2022
The recurrence-free survival curve for two risk factors; the tumor diameter and the presence of active HCV infection. The recurrence-free survival was shorter in patients with larger tumors (p = 0.012).
Shun Kaneko (8735283), Chiaki Maeyashiki (749428), Kaoru Tsuchiya (793697), Kento Inada (8735286), Jun Itakura (554845), Masayuki Kurosaki (156560), Yuka Takahashi (172894), Kenta Takaura (1807024), Kouji Yamashita (12127220), Leona Osawa (8735289), Namiki Izumi (156627), Hiroyuki Nakanishi (698666), Shuhei Sekiguchi (8735292), Tomohiro Muto (12127223), Sakura Kirino (8735280), Yuka Hayakawa (675583), Yutaka Yasui (33074), Nobuharu Tamaki (793693), Mayu Higuchi (793694)   +18 more
core   +1 more source