Results 111 to 120 of about 10,866,611 (334)

Space shuttle SRM plume expansion sensitivity analysis [PDF]

The exhaust plumes of the space shuttle solid rocket motors can have a significant effect on the base pressure and base drag of the shuttle vehicle. A parametric analysis was conducted to assess the sensitivity of the initial plume expansion angle of ...
Penny, M. M., Smith, S. D., Tevepaugh, J. A.   +2 more
core   +1 more source

Local and global sensitivity analysis for railway upgrading between hydrogen fuel cell and electrification

High-Speed Railway
In the field of rail transit, the UK Department of Transport stated that it will realize a comprehensive transformation of UK railways by 2050, abandoning traditional diesel trains and upgrading them to new environmentally friendly trains.
Yizhe Zhang, Zhongbei Tian, Kangrui Jiang, Stuart Hillmansen, Clive Roberts   +4 more
doaj   +1 more source

Local and Global Sensitivity Analysis of Cr (VI) Geogenic Leakage Under Uncertain Environmental Conditions

Water Resources Research, 2018
We focus on the joint application of local and global sensitivity analyses to characterize propagation of model parameter uncertainties to outputs of subsurface water geochemical models.
G. Ceriotti, L. Guadagnini, G. Porta, A. Guadagnini   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Supermodular Locality Sensitive Hashes

, 2018
In this work, we show deep connections between Locality Sensitive Hashability and submodular analysis. We show that the LSHablility of the most commonly analyzed set similarities is in one-to-one correspondance with the supermodularity of these similarities when taken with respect to the symmetric difference of their arguments.
Berman, Maxim, Blaschko, Matthew B.
openaire   +2 more sources

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Sensitivity analysis in linear models

Special Matrices, 2016
In this work, we consider the general linear model or its variants with the ordinary least squares, generalised least squares or restricted least squares estimators of the regression coefficients and variance.
Liu Shuangzhe, Ma Tiefeng, Liu Yonghui
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

RDDA: Rectified Discriminatory Delta-Adjust

IEEE Access
This paper introduces Rectified Discriminatory Delta-Adjust (RDDA), a novel methodology that enhances interpolation-based predictive modeling through adaptive sensitivity parameters.
Ziad F. Doughan, Sari S. Itani
doaj   +1 more source