Results 51 to 60 of about 10,866,611 (334)
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Results in EngineeringThis study investigates the local and global sensitivity of five critical durability parameters affecting concrete performance in chloride environments: concrete cover thickness (d), apparent chloride diffusion coefficient (Dₐₚₚ), surface chloride ...
Lingjie Wu +3 more
doaj +1 more source
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
A Network Analysis-Based Distributed Load Shedding Strategy for Voltage Collapse Prevention
IEEE Access, 2019 This paper proposes a network analysis-based distributed load shedding strategy for voltage collapse prevention. The two-level framework of the distributed load shedding strategy is proposed. The lower one is consisted of local load shedding controllers,
Aina Tian, Xiaoming Mou
doaj +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Rapid adaptive evolution of colour vision in the threespine stickleback radiation. [PDF]
, 2016 Vision is a sensory modality of fundamental importance for many animals, aiding in foraging, detection of predators and mate choice. Adaptation to local ambient light conditions is thought to be commonplace, and a match between spectral sensitivity and ...
Heckman, Nancy +4 more
core
Molecular Pain, 2008 Background - The chronic use of opioids prior to surgery leads to lowered pain thresholds and exaggerated pain levels after these procedures. Several mechanisms have been proposed to explain this heightened sensitivity commonly termed opioid-induced ...
Angst Martin S +5 more
doaj +1 more source
On Locality-Sensitive Orderings and Their Applications [PDF]
SIAM Journal on Computing, 2020 For any constant $d$ and parameter $\varepsilon > 0$, we show the existence of (roughly) $1/\varepsilon^d$ orderings on the unit cube $[0,1)^d$, such that any two points $p,q\in [0,1)^d$ that are close together under the Euclidean metric are "close together" in one of these linear orderings in the following sense: the only points that could lie ...
Chan, Timothy M. +2 more
openaire +5 more sources
Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
FEBS Letters, EarlyView.CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source